FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person* GLAXOSMITHKLINE PLC (Last) (First) (Middle) 980 GREAT WEST ROAD (Street) BRENTFORD MIDDLESEX X0 TW8 9GS (City) (State) (Zip)	2. Date of Event Requiring Statement (Month/Day/Year) 12/18/2006	3. Issuer Name and Ticker or Trading Symbol EPIX Pharmaceuticals, Inc. [ EPIX ]
		4. Relationship of Reporting Person(s) to Issuer (Check all applicable) Director X 10% Owner Officer (give title below) Other (specify below)	5. If Amendment, Date of Original Filed (Month/Day/Year)
			6. Individual or Joint/Group Filing (Check Applicable Line) X Form filed by One Reporting Person Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common stock	4,266,795	I	by Corporation(1)(2)(3)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. On December 18, 2006, Glaxo Group Limited ("GGL") and SmithKline Beecham Corporation ("SBCorp"), indirect wholly-owned subsidiaries of Reporting Person, purchased 1,629,689 and 1,379,338 shares of Common stock, respectively, pursuant to a Stock Purchase Agreement dated December 11, 2006 between GGL, SBCorp and the Issuer.

2. S.R.One, Limited ("SRO"), another indirect wholly-owned subsidiary of Reporting Person, previously acquired 1,257,768 shares of Common stock but was not required to file under Section 16(a) of the Securities Exchange Act of 1934, as amended (the "Act").

3. All shares covered by this report are beneficially owned by indirect wholly-owned subsidiaries of Reporting Person. The Reporting Person may be deemed, for purposes of Section 16 of the Act to be the beneficial owner of GGL, SBCorp and SRO and, therefore, may be deemed to be a "10 percent beneficial owner" for purposes of Section 16 of the Act.

	Victoria A. Whyte, Deputy Secretary	12/21/2006
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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