CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands |
12 Months Ended |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
| Operating activities |
|
|
|
| Net loss |
$ (94,176)
|
$ (27,255)
|
$ (17,917)
|
| Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
| Depreciation and amortization |
655
|
171
|
187
|
| Lease incentive |
(34)
|
(34)
|
(34)
|
| Stock-based compensation expense |
5,787
|
2,209
|
22
|
| Non cash interest expense |
|
6
|
7
|
| Change in fair value of derivative liability |
|
|
7
|
| Changes in operating assets and liabilities: |
|
|
|
| Accounts receivable |
(2,129)
|
|
|
| Inventories |
(1,316)
|
|
|
| Prepaid expenses and other assets |
(923)
|
(659)
|
183
|
| Refundable PDUFA fee |
|
2,335
|
(2,335)
|
| Accounts payable |
5,569
|
1,298
|
990
|
| Accrued expenses |
6,570
|
362
|
943
|
| Deferred revenue |
4,944
|
|
|
| Net cash used in operating activities |
(75,053)
|
(21,567)
|
(17,947)
|
| Investing activities |
|
|
|
| Purchase of intangible assets |
(2,500)
|
|
|
| Purchases of property and equipment |
(477)
|
(362)
|
(8)
|
| Net cash used in investing activities |
(2,977)
|
(362)
|
(8)
|
| Financing activities |
|
|
|
| Proceeds from issuance of convertible bridge note |
|
|
5,000
|
| Proceeds from issuances of common stock from public offerings, net of issuance costs of $845 and $2,408 |
137,340
|
72,029
|
|
| Proceeds from issuances of common stock from employee stock purchase plans |
442
|
|
|
| Proceeds from notes payable, net of original note payoff |
|
|
7,056
|
| Proceeds from issuance of Series D convertible redeemable preferred stock, net of issuance costs of $193 |
|
44,807
|
|
| Repayment of term note |
(2,667)
|
(1,286)
|
(28)
|
| Repayment of lease note payable |
|
(59)
|
(62)
|
| Restricted cash |
|
(16)
|
|
| Proceeds from the exercise of stock options |
443
|
517
|
72
|
| Net cash provided by financing activities |
135,558
|
115,992
|
12,038
|
| Net increase (decrease) in cash and cash equivalents |
57,528
|
94,063
|
(5,917)
|
| Cash and cash equivalents at beginning of period |
95,697
|
1,634
|
7,551
|
| Cash and cash equivalents at end of period |
153,225
|
95,697
|
1,634
|
| Supplemental disclosure of cash flow information |
|
|
|
| Cash paid for interest |
284
|
353
|
181
|
| Supplemental disclosure of non-cash activities |
|
|
|
| Acquisition of property and equipment in accrued expenses |
$ 81
|
|
|
| Preferred stock conversion to common stock |
|
120,302
|
|
| Extinguishment of preferred stock |
|
31,184
|
|
| Accruals of dividends and accretion to redemption value |
|
24,572
|
3,300
|
| Conversion of bridge note to preferred stock |
|
5,000
|
|
| Repayment of term note with proceeds of notes payable |
|
|
944
|
| Series C convertible redeemable preferred stock |
|
|
|
| Supplemental disclosure of non-cash activities |
|
|
|
| Accruals of dividends and accretion to redemption value |
|
2,996
|
$ 960
|
| Series D convertible redeemable preferred stock |
|
|
|
| Supplemental disclosure of non-cash activities |
|
|
|
| Accruals of dividends and accretion to redemption value |
|
$ 1,245
|
|