Document and Entity Information Statement [Table] Statement [Line Items] Statement Entity Registrant Name Entity Central Index Key Document Type Document Period End Date Amendment Flag Current Fiscal Year End Date Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Filer Category Entity Public Float Entity Common Stock, Shares Outstanding Document Fiscal Year Focus Document Fiscal Period Focus CONSOLIDATED BALANCE SHEETS Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Cash and cash equivalents Accounts Receivable, Net, Current Accounts receivable, net Inventory, Net Inventory Total inventory Inventory capitalized Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Total prepaid expenses and other current assets Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Intangible Assets, Net (Including Goodwill) Intangible assets, net Restricted Cash and Cash Equivalents, Noncurrent Restricted cash Other Assets, Noncurrent Other long-term assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and shareholders' equity (deficit) Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Accrued Liabilities, Current Accrued expenses Total accrued expenses Deferred Revenue Deferred revenue Loans Payable, Current Current portion of term loan payable Liabilities, Current Total current liabilities Incentive from Lessor Lease incentive obligation Loans Payable, Noncurrent Term loan payable, long-term Liabilities Total liabilities Commitments and Contingencies, Amount Commitments and contingencies (see Note 9) Stockholders' Equity Attributable to Parent [Abstract] Shareholders’ equity (deficit): Preferred Stock, Value, Issued Preferred stock, $0.001 par value; authorized shares - 5,000,000 at December 31, 2016 and December 31, 2015; issued and outstanding shares - none at December 31, 2016 and December 31, 2015 Common Stock, Value, Issued Common stock, $0.001 par value; authorized shares - 100,000,000 at December 31, 2016 and December 31, 2015; issued and outstanding shares - 29,364,100 at December 31, 2016 and 20,739,351 at December 31, 2015 Additional Paid in Capital Additional paid-in capital Retained Earnings (Accumulated Deficit) Accumulated deficit Accumulated deficit Treasury Stock, Carrying Basis Treasury stock Stockholders' Equity Attributable to Parent Total shareholders’ equity Liabilities and Equity Total liabilities and shareholders’ equity Temporary Equity, Shares Authorized Convertible redeemable preferred stock, authorized shares Authorized preferred stock (in shares) Temporary Equity, Shares Issued Balance at end of year (in shares) Balance at beginning of year (in shares) Convertible redeemable preferred stock, issued shares Preferred stock issued (in shares) Temporary Equity, Shares Outstanding Convertible redeemable preferred stock, outstanding shares Preferred stock outstanding (in shares) Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, authorized shares Preferred Stock, Shares Issued Preferred stock, issued shares Preferred Stock, Shares Outstanding Preferred stock, outstanding shares Common Stock, Par or Stated Value Per Share Par value of common stock (in dollars per share) Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, authorized shares Authorized common stock (in shares) Common Stock, Shares, Issued Common stock, issued shares Common stock issued (in shares) Common Stock, Shares, Outstanding Common stock, outstanding shares Common stock outstanding (in shares) CONSOLIDATED STATEMENTS OF OPERATIONS Revenues Sales Revenue, Goods, Net Product revenues, net Product revenues, net Operating Expenses [Abstract] Costs and expenses Cost of Goods Sold Cost of product revenues Cost of product revenues Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Operating Expenses Total costs and expenses Operating Income (Loss) Loss from operations Loss from operations Other Expenses [Abstract] Other expense (income): Interest Expense Interest expense, net Gains (Losses) on Extinguishment of Debt Gain on extinguishment of debt Gain on extinguishment Unrealized Gain (Loss) on Derivatives Change in fair value of derivative liability Other Nonoperating Income (Expense) Total other expense, net Other expense, net Net Income (Loss) Attributable to Parent Net loss Net loss Earnings Per Share, Basic and Diluted Loss per share - basic and diluted Weighted Average Number of Shares Outstanding, Basic and Diluted Weighted-average number of common shares used in net loss per share-basic and diluted (in shares) Weighted-average shares - basic and diluted No definition available. STATEMENTS OF CONVERTIBLE REDEEMABLE PREFERRED STOCK Increase (Decrease) in Temporary Equity [Roll Forward] Increase (decrease) in convertible redeemable preferred stock Temporary Equity, Carrying Amount, Attributable to Parent Balance at end of year Balance at beginning of year Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest Balance at end of year Balance at beginning of year Stock Issued During Period, Value, Stock Options Exercised Exercise of common stock options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Exercise of common stock options, shares Stock Issued During Period, Shares, Restricted Stock Award, Gross Issuance of restricted stock awards to employees, shares Represents the combined value of accretion of temporary equity during the period due to unpaid dividends and accretion of temporary equity to its redemption value during the period. Temporary Equity, Accretion of Dividends and Accretion to Redemption Value Accruals of dividends and accretion to redemption value Accruals of dividends and accretion to redemption value Amount of decrease (increase) in additional paid in capital (APIC) and adjustment to retained earnings for the increase in carrying amount of redeemable preferred stock that is classified as temporary equity. Adjustments to Additional Paid in Capital and Retained Earnings, Increase in Carrying Amount of Redeemable Preferred Stock Accruals of dividends and accretion to redemption value Value of stock issued as a result of the exercise of warrants. Stock Issued During Period Value Warrants Exercised Exercise of warrants Number of warrants exercised during the current period. Stock Issued During Period Shares Warrants Exercised Exercise of warrants (in shares) Temporary Equity, Stock Issued During Period, Value, New Issues Aggregate consideration Issuance of convertible redeemable preferred stock, net of issuance costs Number of shares of temporary equity issued during the period. Temporary Equity, Stock Issued During Period, Shares, New Issues Issuance of stock (in shares) Issuance of convertible redeemable preferred stock, net of issuance costs, shares The gross value of preferred stock issued during the period upon the conversion of convertible securities. Preferred Stock Issued During Period Value Conversion Of Convertible Securities Conversion of notes to convertible redeemable preferred stock Number of preferred shares issued during the period as a result of the conversion of convertible securities. Preferred Stock Issued During Period Shares Conversion Of Convertible Securities Conversion of notes to convertible redeemable preferred stock, shares Value of temporary equity preferred stock dividends extinguished during the period. Temporary Equity Extinguishment Prior Preferred Stock Dividends During Period Value Extinguishment of prior preferred stock dividends Amount of (decrease) increase in additional paid in capital (APIC) and adjustment to retained earnings for the decrease in carrying amount of redeemable preferred stock that is classified as temporary equity. Adjustments To Additional Paid In Capital And Retained Earnings Decrease In Carrying Amount Of Redeemable Preferred Stock Dividends Extinguishment of prior preferred stock dividends Stock Issued During Period, Value, Conversion of Convertible Securities Conversion of preferred stock to common stock Stock Issued During Period, Shares, Conversion of Convertible Securities Conversion of preferred stock to common stock, shares Stock Issued During Period, Value, New Issues Public offering of common stock, net of issuance costs Stock Issued During Period, Shares, New Issues Public offering of common stock, net of issuance costs, shares Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance for employee stock purchase plan Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance for employee stock purchase plan, shares Stock Issued During Period, Value, Stock Dividend Issuance of common stock in payment of accrued dividends Stock Issued During Period, Shares, Stock Dividend Stock Issued During Period, Shares, Stock Dividend Issuance of common stock in payment of accrued dividends, shares Treasury Stock, Retired, Cost Method, Amount Retirement of treasury stock Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary, Sale of Stock [Line Items] Sale of stock Amount of decrease to temporary equity resulting from direct costs associated with issuing stock. Includes, but is not limited to, legal and accounting fees and direct costs associated with stock issues under a shelf registration. Temporary Equity, Stock Issued, Issuance Costs Issuance costs Closing costs Payments of Stock Issuance Costs Issuance costs CONSOLIDATED STATEMENTS OF CASH FLOWS Net Cash Provided by (Used in) Operating Activities, Continuing Operations [Abstract] Operating activities Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Depletion and Amortization Depreciation and amortization This element represents the amortization of the deferred credit for an incentive or inducement received by a lessee from a lessor, in order to motivate the lessee to enter the lease agreement, amortized over the term of the lease. Amortization of Incentive from Lessor Lease incentive Share-based Compensation Stock-based compensation expense Amortization of Financing Costs and Discounts Non cash interest expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Accounts Receivable Accounts receivable Increase (Decrease) in Inventories Inventories Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other assets Increase (Decrease) in Deposits Outstanding Refundable PDUFA fee Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued expenses Increase (Decrease) in Deferred Revenue Deferred revenue Net Cash Provided by (Used in) Operating Activities, Continuing Operations Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities, Continuing Operations [Abstract] Investing activities Payments to Acquire Intangible Assets Purchase of intangible assets Payments to Acquire Property, Plant, and Equipment Purchases of property and equipment Net Cash Provided by (Used in) Investing Activities, Continuing Operations Net cash used in investing activities Net Cash Provided by (Used in) Financing Activities, Continuing Operations [Abstract] Financing activities Proceeds from Short-term Debt Proceeds from issuance of convertible bridge note Proceeds from Issuance of Common Stock Net proceeds from public offering Proceeds from issuances of common stock from public offerings, net of issuance costs of $845 and $2,408 Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Excluding Stock Options Proceeds from issuances of common stock from employee stock purchase plans Proceeds from (Repayments of) Notes Payable Proceeds from notes payable, net of original note payoff Proceeds from Issuance of Preferred Stock and Preference Stock Proceeds from issuance of Series D convertible redeemable preferred stock, net of issuance costs of $193 Maturities of Senior Debt Repayment of term note Repayments of Long-term Loans from Vendors Repayment of lease note payable Increase in Restricted Cash Restricted cash Proceeds from Stock Options Exercised Proceeds from the exercise of stock options Net Cash Provided by (Used in) Financing Activities, Continuing Operations Net cash provided by financing activities Net Cash Provided by (Used in) Continuing Operations Net increase (decrease) in cash and cash equivalents Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash flow information Interest Paid Cash paid for interest Noncash Investing and Financing Items [Abstract] Supplemental disclosure of non-cash activities Noncash or Part Noncash Acquisition, Fixed Assets Acquired Acquisition of property and equipment in accrued expenses Conversion of Stock, Amount Converted Preferred stock conversion to common stock Amountof Preferred stock extinguished in non cash. Noncash or Part Noncash Extinguishment of preferred Stock Extinguishment of preferred stock Debt Conversion, Original Debt, Amount Conversion of bridge note to preferred stock Notes Reduction Repayment of term note with proceeds of notes payable Schedule of Stock by Class [Table] Class of Stock [Line Items] Equity Preferred stock NATURE OF BUSINESS. Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] NATURE OF BUSINESS SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES. Significant Accounting Policies [Text Block] SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES NET LOSS PER COMMON SHARE. Earnings Per Share [Text Block] NET LOSS PER COMMON SHARE INVENTORY. Inventory Disclosure [Text Block] INVENTORY PREPAID EXPENSES AND OTHER CURRENT ASSETS. The entire disclosure for prepaid expenses and other current assets. Prepaid Expenses and Other Current Assets [Text Block] PREPAID EXPENSES AND OTHER CURRENT ASSETS PROPERTY AND EQUIPMENT. Property, Plant and Equipment Disclosure [Text Block] PROPERTY AND EQUIPMENT INTANGIBLE ASSETS. Intangible Assets Disclosure [Text Block] INTANGIBLE ASSETS ACCRUED EXPENSES. Accounts Payable and Accrued Liabilities Disclosure [Text Block] Accrued Expenses COMMITMENTS AND CONTINGENCIES. Commitments and Contingencies Disclosure [Text Block] COMMITMENTS AND CONTINGENCIES TERM LOAN PAYABLE. Debt Disclosure [Text Block] TERM LOAN PAYABLE WARRANTS. The entire disclosure for information about warrants or rights issued, which may include the title of issue of securities called for by warrants and rights outstanding, the aggregate amount of securities called for by warrants and rights outstanding, the date from which the warrants or rights are exercisable, and the price at which the warrant or right is exercisable. Warrants Disclosure [Text Block] WARRANTS EQUITY. Combined disclosure for securities with redemption features that are outside the control of the issuer and shareholders' equity which may include, for temporary equity, a description by series, value, shares authorized, shares issued and outstanding, redemption price per share and subscription receivable; and for stockholders' equity, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income. Temporary Equity and Stockholders' Equity Note Disclosure [Text Block] EQUITY STOCK BASED COMPENSATION. Disclosure of Compensation Related Costs, Share-based Payments [Text Block] STOCK BASED COMPENSATION INCOME TAXES. Income Tax Disclosure [Text Block] INCOME TAXES EMPLOYEE BENEFITS. Pension and Other Postretirement Benefits Disclosure [Text Block] EMPLOYEE BENEFITS UNAUDITED QUARTERLY OPERATING RESULTS. Quarterly Financial Information [Text Block] UNAUDITED QUARTERLY OPERATING RESULTS SUBSEQUENT EVENTS. Subsequent Events [Text Block] SUBSEQUENT EVENTS Use of Estimates, Policy [Policy Text Block] Use of Estimates Fair Value of Financial Instruments, Policy [Policy Text Block] Fair Value Measurements Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk Cash and Cash Equivalents, Unrestricted Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Inventory, Policy [Policy Text Block] Inventory Property, Plant and Equipment, Policy [Policy Text Block] Property and Equipment Intangible Assets, Finite-Lived, Policy [Policy Text Block] Intangible Assets Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Restricted Cash Revenue Recognition, Policy [Policy Text Block] Revenue Recognition Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Disclosure of accounting policy for costs incurred related to filing and pursuing patent applications. Patent Costs Incurred, Policy [Policy Text Block] Patent Costs Advertising Cost, Policy, Expensed Advertising Cost [Policy Text Block] Advertising and Product Promotion Costs Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block] Stock-Based Compensation