CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Revenues      
Product revenues, net $ 1,711    
Costs and expenses      
Cost of product revenues 213    
Research and development 14,948 $ 7,975 $ 14,959
Selling, general and administrative 80,632 18,932 2,706
Total costs and expenses 95,793 26,907 17,665
Loss from operations (94,082) (26,907) (17,665)
Other expense (income):      
Interest expense, net 94 439 252
Gain on extinguishment of debt   (91)  
Change in fair value of derivative liability     7
Total other expense, net 94 348 252
Net loss $ (94,176) $ (27,255) $ (17,917)
Loss per share - basic and diluted $ (3.88) $ (1.48) $ (22.72)
Weighted-average shares - basic and diluted 24,262,945 13,542,282 933,997