FORM 3 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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1. Name and Address of Reporting Person*
Montgomery Bobby Dwayne

(Last) (First) (Middle)
C/O OSIRIS THERAPEUTICS, INC.
7015 ALBERT EINSTEIN DRIVE

(Street)
COLUMBIA MD 21046

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
09/17/2015
3. Issuer Name and Ticker or Trading Symbol
OSIRIS THERAPEUTICS, INC. [ OSIR ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
Director 10% Owner
X Officer (give title below) Other (specify below)
Chief Business Officer
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Incentive Stock Option (right to buy) 04/21/2015(1) 04/21/2024 Common Stock 25,000 12.93 D
Incentive Stock Option (right to buy) 03/06/2016(2) 03/06/2025 Common Stock 6,803 18.4 D
Non-Qualified Stock Option (right to buy) 03/06/2016(2) 03/06/2025 Common Stock 5,697 18.4 D
Explanation of Responses:
1. Options to purchase 25,000 shares of the common stock of the Registrant shall become exercisable with respect to the underlying shares as to 25% on each April 21, 2015, 2016, 2017 and 2018, assuming the Reporting Person continues to be employed by the Registrant on the vesting date.
2. Options to purchase 12,500 shares of the common stock of the Registrant shall become exercisable with respect to the underlying shares as to 25% on each March 6, 2016, 2017, 2018 and 2019, assuming the Reporting Person continues to be employed by the Registrant on the vesting date.
B. Dwayne Montgomery 09/21/2015
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.