FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
1. Name and Address of Reporting Person*
Powers Linda F

(Last) (First) (Middle)
7600 WISCONSIN AVENUE
7TH FLOOR

(Street)
BETHESDA MD 20814

(City) (State) (Zip)
2. Issuer Name and Ticker or Trading Symbol
NORTHWEST BIOTHERAPEUTICS INC [ NWBT ]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director X 10% Owner
Officer (give title below) Other (specify below)
3. Date of Earliest Transaction (Month/Day/Year)
08/19/2008
4. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
Form filed by One Reporting Person
X Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Promissory Note(1) $1.75 08/19/2008 P $60,000 02/19/2009(2) 02/19/2009(2) Common Stock 34,286 (1) $60,000 I By Fund(3)
1. Name and Address of Reporting Person*
Powers Linda F

(Last) (First) (Middle)
7600 WISCONSIN AVENUE
7TH FLOOR

(Street)
BETHESDA MD 20814

(City) (State) (Zip)
1. Name and Address of Reporting Person*
Hemphill Robert F Jr.

(Last) (First) (Middle)
7500 WISCONSIN AVENUE
7TH FLOOR

(Street)
BETHESDA MD 20814

(City) (State) (Zip)
1. Name and Address of Reporting Person*
Toucan Partners, LLC

(Last) (First) (Middle)
7600 WISCONSIN AVENUE
SUITE 700

(Street)
BETHESDA MD 20814

(City) (State) (Zip)
Explanation of Responses:
1. On August 19, 2008 Toucan Partners, LLC ("Toucan Partners") loaned $1,000,000 to the Issuer pursuant to a Loan Agreement and Promissory Note (the "Note"). Pursuant to the terms of the Note, on the maturity of the Note, up to $60,000 of the accrued interest on the Note shall be convertible at the option of Toucan Partners into common stock of the Issuer at the price of $1.75 per share.
2. The Note matures on February 19, 2009 or, if earlier, upon a default by the Issuer under the Note. In accordance with the terms of the Note, Toucan Partners may convert up to $60,000 of accrued interest at the time of maturity.
3. Consists of securities held of record by Toucan Partners, LLC. Linda Powers is the managing member of Toucan Partners and Linda Powers and Robert Hemphill, Jr. are each members Toucan Partners and, as a result, Ms. Powers and Mr. Hemphill may be deemed to beneficially own the securities reported herein. Each of the reporting persons disclaims beneficial ownership of the securities reported herein except to the extent of his, her or its respective pecuniary interests therein.
Remarks:
/s/ Darren DeStefano, attorney-in-fact 08/21/2008
Darren DeStefano, attorney-in-fact 08/21/2009
Darren DeStefano, attorney-in-fact 08/21/2008
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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