Collaboration and License Agreements - AskBio (Narrative) (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Operating expenses $ 89,674 $ 73,418 $ 59,132
AskBio License      
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]      
Operating expenses $ 2,700 $ 3,800  
Cost share percentage 50.00% 50.00%