Stock-Based Compensation - Compensation expense (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Stock-based compensation expense    
Stock-based compensation expense $ 8,642 $ 8,488
Research and development expenses    
Stock-based compensation expense    
Stock-based compensation expense 2,531 2,111
General and administrative expenses    
Stock-based compensation expense    
Stock-based compensation expense 6,111 $ 6,377
Stock options.    
Stock-based compensation expense    
Unrecognized compensation cost $ 60,400  
Unrecognized compensation cost expected to be recognized over a weighted average period 2 years 4 months 24 days  
Service Based Stock Options    
Stock-based compensation expense    
Purchase of an aggregate shares of common stock 2,459,661  
Options exercise price $ 12.53  
Weighted average grant-date fair value (per share) $ 8.37