Stock-Based Compensation - Compensation expense (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Jun. 30, 2018
Stock-based compensation expense        
Stock-based compensation expense $ 10,604 $ 5,902 $ 20,082 $ 8,515
Unrecognized compensation cost 89,500   $ 89,500  
Unrecognized compensation cost expected to be recognized over a weighted average period     2 years 4 months 24 days  
Research and development expenses        
Stock-based compensation expense        
Stock-based compensation expense 2,612 719 $ 4,603 984
General and administrative expenses        
Stock-based compensation expense        
Stock-based compensation expense $ 7,992 $ 5,183 $ 15,479 $ 7,531