Payments due Lessee, Operating Lease, Liability, to be Paid Net loss Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Other long-term liabilities Increase (Decrease) in Other Noncurrent Liabilities Principal amount of long‑term debt Long-Term Debt, Gross Accrued employee termination benefits Accrued Employee Termination Benefits, Current Accrued Employee Termination Benefits, Current Entity Address, Postal Zip Code Entity Address, Postal Zip Code Annual increase of shares reserved for awards (as a percent) Share-based Compensation Arrangement by Share-based Payment Award, Annual Increase Percentage Annual increase of the shares (or other type of equity) for awards under the equity-based compensation plan as as a proportion of outstanding capital stock. Income tax benefits - operating losses incurred Income Tax Benefits For Net Operating Losses Incurred The amount of income tax benefits for the net operating losses incurred. Assets held for sale Assets Held-for-sale, Not Part of Disposal Group Preferred stock, shares outstanding (in shares) Preferred Stock, Shares Outstanding Debt Instrument [Axis] Debt Instrument [Axis] Property, plant and equipment, gross Property, Plant and Equipment, Gross Maximum amount outstanding Line of Credit Facility, Maximum Borrowing Capacity Income Tax Disclosure [Abstract] Income Tax Disclosure [Abstract] Balance at beginning of period Balance at end of period Restructuring Reserve Additional paid-in capital Additional Paid in Capital Financial Instruments [Domain] Financial Instruments [Domain] Variable interest rate Debt Instrument, Basis Spread on Variable Rate Statistical Measurement [Domain] Statistical Measurement [Domain] Borrowing Proceeds from Issuance of Debt Issuance of common stock upon exercise of stock options (in shares) Exercised (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Net deferred tax assets Deferred Tax Assets, Net Weighted-average discount rate - operating leases Operating Lease, Weighted Average Discount Rate, Percent Interest rate (as a percent) Debt Instrument, Interest Rate, Stated Percentage Market-Based Stock Options Market-Based Stock Options Stock options awarded to employees for meeting certain closing prices of its common stock. Share-based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Domestic Tax Authority Domestic Tax Authority [Member] Net loss Net loss Net loss Net loss Net Income (Loss) Attributable to Parent Lessee, Lease, Description [Table] Lessee, Lease, Description [Table] Audit Information [Abstract] Audit Information Diluted net loss per share attributable to common stockholders Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] Antidilutive securities excluded from computation of of diluted weighted average shares outstanding Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Minimum lease payments Lessee, Operating Lease, Liability, to be Paid [Abstract] Thereafter Lessee, Operating Lease, Liability, to be Paid, after Year Five Equity Component [Domain] Equity Component [Domain] Scenario [Axis] Scenario [Axis] Prepayment fee in first year Debt Instrument, Prepayment Rate One Represents the prepayment rate if prepayment occurs in first year. Assets Assets, Fair Value Disclosure Restructuring Plan [Axis] Restructuring Plan [Axis] Leases Lessee, Operating Leases [Text Block] Leases Lessee, Lease, Description [Line Items] Related Party [Domain] Related Party [Domain] Fair Value Measurements Fair Value Measurement, Policy [Policy Text Block] Plan Name [Axis] Plan Name [Axis] Supplemental cash flow information: Supplemental Cash Flow Information [Abstract] Forfeited (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Executive Officer Executive Officer [Member] One-month LIBOR Debt Instrument, Description of Variable Rate Basis Plan Name [Domain] Plan Name [Domain] State operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, State and Local Statement of Cash Flows [Abstract] Statement of Cash Flows [Abstract] Entity Address, State or Province Entity Address, State or Province Level 1 Fair Value, Inputs, Level 1 [Member] Outstanding at the beginning (in years) Outstanding at the end (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term Award Type [Axis] Award Type [Axis] Net cash used in operating activities Net cash provided by (used in) operating activities Net Cash Provided by (Used in) Operating Activities Non-cash interest expense Other Noncash Expense Operating lease liabilities Operating Lease, Liability, Current Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Lease cost: Lease, Cost [Abstract] Schedule of accrued expenses and other current liabilities Schedule of Accrued Liabilities and Other Current Liabilities [Table Text Block] Tabular disclosure of the components of accrued liabilities and other current liabilities. Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table] Restructuring and related cost, expected cost Restructuring and Related Cost, Expected Cost Forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period Increases recorded to income tax provision Valuation Allowance, Deferred Tax Asset, Increase in Income Tax Provision Amount of increase in the valuation allowance for a specified deferred tax asset. Performance-based vesting Performance-based vesting Represents a share based compensation award with vesting based on achievement of performance conditions. Document Annual Report Document Annual Report Long-term debt, net of discount Long‑term debt, net of discount and current portion Long-Term Debt, Excluding Current Maturities Total liabilities Liabilities Accrued expenses and other current liabilities Increase (Decrease) in Accrued Expenses and Other Current Liabilities The increase (decrease) during the reporting period in the amounts of accrued expenses and other current liabilities. Weighted average remaining lease term - operating leases Operating Lease, Weighted Average Remaining Lease Term Share-Based Compensation Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Cash flows from investing activities: Net Cash Provided by (Used in) Investing Activities [Abstract] Amortization (accretion) of premium (discount) on investments Investment Income, Net, Amortization of Discount and Premium Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs of $800 Stock Issued During Period, Value, New Issues Entity Common Stock, Shares Outstanding Entity Common Stock, Shares Outstanding Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Restructuring and impairment charges Restructuring Costs and Asset Impairment Charges Schedule of property, plant and equipment, Net Property, Plant and Equipment [Table Text Block] Investments Debt Securities, Available-for-Sale, Current Restructuring and related cost, number of positions eliminated Restructuring and Related Cost, Number of Positions Eliminated Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Document Type Document Type Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] Decreases recorded as benefit to income tax provision Valuation Allowance, Deferred Tax Asset, Decreases Recorded As Benefit To Income Tax Provision Valuation Allowance, Deferred Tax Asset, Decreases Recorded As Benefit To Income Tax Provision Estimated useful life Property, Plant and Equipment, Useful Life Number of shares Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] Laboratory equipment Laboratory equipment Tangible personal property used in laboratory. Assets: Assets, Fair Value Disclosure [Abstract] Restructuring Type [Axis] Restructuring Type [Axis] Weighted average grant date fair value - beginning of the period (in dollars per share) Weighted average grant date fair value - end of the period (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value Debt Debt Disclosure [Text Block] Product and Service [Domain] Product and Service [Domain] Entity Shell Company Entity Shell Company 2023 Lessee, Operating Lease, Liability, to be Paid, Year One Financial Instrument [Axis] Financial Instrument [Axis] Embedded lease contracts Embedded lease contracts Represents information relating to embedded lease contracts. Document Period End Date Document Period End Date Restructuring and Impairment Charges Restructuring, Impairment, and Other Activities Disclosure [Text Block] Net of commissions, underwriting discounts and offering costs Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Manufacturing equipment Manufacturing equipment Represents the information pertaining to manufacturing equipment. Total assets Assets Debt Disclosure [Abstract] Debt Disclosure [Abstract] Earnings Per Share [Abstract] Earnings Per Share [Abstract] Income Statement Location [Axis] Income Statement Location [Axis] Antidilutive Securities [Axis] Antidilutive Securities [Axis] Schedule of Restructuring and Related Costs [Table] Schedule of Restructuring and Related Costs [Table] Contract termination costs Contract Termination [Member] Less: Current portion of long‑term debt Long-Term Debt, Current Maturities Numerator: Net Income (Loss) Available to Common Stockholders, Basic [Abstract] 2027 Lessee, Operating Lease, Liability, to be Paid, Year Five Options exercise price (in dollars per share) Exercised (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Net cash provided by (used in) financing activities Net Cash Provided by (Used in) Financing Activities Accounting Policies [Abstract] Accounting Policies [Abstract] Stockholders' Equity Note [Abstract] Stockholders' Equity Note [Abstract] Principal amount of each tranche of term loans Debt Instrument, Unused Borrowing Capacity, Amount Accrued employee compensation and benefits Employee-related Liabilities, Current Variable lease cost Variable Lease, Cost Stockholders' equity: Stockholders' Equity Attributable to Parent [Abstract] Net Loss per Share Earnings Per Share [Text Block] Schedule of assumptions used to determine the fair value of stock awards granted Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Disposal Group, Disposed of by Sale, Not Discontinued Operations Disposal Group, Disposed of by Sale, Not Discontinued Operations [Member] Unrealized gains (losses) on investments, tax OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, Tax Cash Equivalents Cash and Cash Equivalents, Policy [Policy Text Block] Award Type [Domain] Award Type [Domain] Increase in deferred tax asset valuation allowance Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent Unrecognized compensation cost expected to be recognized over a weighted average period Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition Gain on debt extinguishment Gain on debt extinguishment Gain (Loss) on Extinguishment of Debt Options exercisable (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term Restructuring Plan [Domain] Restructuring Plan [Domain] Computer equipment Computer Equipment [Member] Entity Registrant Name Entity Registrant Name Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs (in shares) Shares issued (in shares) Stock Issued During Period, Shares, New Issues Subsequent Events Subsequent Events [Text Block] Expected dividend yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Restructuring Reserve [Roll Forward] Restructuring Reserve [Roll Forward] Entity Address, City or Town Entity Address, City or Town Leases [Abstract] Leases [Abstract] Operating expenses: Operating Expenses [Abstract] Net operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards Minimum Minimum [Member] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Entity Emerging Growth Company Entity Emerging Growth Company Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Proceeds from borrowings under loan and security agreement Proceeds from Issuance of Secured Debt Market based and service based vesting Market based and service based vesting Share-based payment arrangement granting right, subject to common stock closing prices and service based vesting requirements, to purchase or sell certain number of shares at predetermined price for specified period of time. Issuance costs Debt Issuance Costs, Net Commitments and Contingencies Disclosure [Abstract] Commitments and Contingencies Disclosure [Abstract] Auditor Name Auditor Name Investments and Fair Value of Financial Assets and Liabilities Fair Value Disclosures [Text Block] Trading Symbol Trading Symbol Entity File Number Entity File Number Capitalized research and development expense Deferred Tax Assets, Capitalized Research and Development Expense Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences, capitalized research and development expense. Federal and state research and development tax credits Effective Income Tax Rate Reconciliation, Tax Credit, Research, Percent Accrued final interest payment Interest Payable, Current Research and development Research and Development Expense Disposal Group Classification [Axis] Disposal Group Classification [Axis] Restricted stock units issued (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Restricted Stock Units (RSUs) Restricted Stock Units (RSUs) [Member] Effective income tax rate Effective Income Tax Rate Reconciliation, Percent Vested and expected to vest (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number 2018 ESPP 2018 ESPP [Member] 2018 ESPP Use of Estimates Use of Estimates, Policy [Policy Text Block] Cash equivalents Cash and Cash Equivalents, Fair Value Disclosure Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Equity Option Equity Option [Member] Accounts payable Increase (Decrease) in Accounts Payable One-month U.S. LIBOR London Interbank Offered Rate (LIBOR) [Member] Subsequent Events [Abstract] Revenue Revenues Increase in number of authorized shares reserved for issuance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized Restructuring and related cost, cost incurred to date Restructuring and Related Cost, Cost Incurred to Date Income Taxes Income Tax Disclosure [Text Block] Manufacturing facility Manufacturing Facility [Member] Cash paid for interest Interest Paid, Excluding Capitalized Interest, Operating Activities Net loss per share, basic (in dollars per share) Earnings Per Share, Basic Accrued general and administrative expenses Accrued General And Administrative Expenses Current The amount of current portion of accrued general and administrative expenses as at the end of the reporting period. 2025 Lessee, Operating Lease, Liability, to be Paid, Year Three Counterparty Name [Domain] Counterparty Name [Domain] Total stockholders' equity Balances at beginning of period Balances at end of period Stockholders' Equity Attributable to Parent Weighted average grant date fair value- forfeited (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Entity Interactive Data Current Entity Interactive Data Current Fair Value, by Balance Sheet Grouping [Table] Fair Value, by Balance Sheet Grouping [Table] Property, Plant and Equipment [Table] Property, Plant and Equipment [Table] Changes in operating assets and liabilities: Increase (Decrease) in Operating Capital [Abstract] U.S. government money market funds Money Market Funds [Member] Accumulated deficit Retained Earnings [Member] Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration] Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal, Statement of Income or Comprehensive Income [Extensible Enumeration] Total lease cost Lease, Cost Common stock Common Stock [Member] Prepayment fee in third year Debt Instrument, Prepayment Rate Three Represents the prepayment rate if prepayment occurs in third year. Schedule of lease cost and lease liabilities for the Company's lease portfolio Lease, Cost [Table Text Block] Payment of long-term debt Payments for Repurchase of Common Stock Number of shares remained available for future issuance (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Schedule of restricted stock unit activity Schedule of Nonvested Restricted Stock Units Activity [Table Text Block] Income Taxes Income Tax, Policy [Policy Text Block] Operating Loss Carryforwards [Line Items] Operating Loss Carryforwards [Line Items] Statement [Table] Statement [Table] Weighted average grant date fair value- vested (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value Furniture and fixtures Furniture and Fixtures [Member] Current assets: Assets, Current [Abstract] Uncertain tax positions Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense Operating lease liabilities, net of current portion Operating Lease, Liability, Noncurrent Research and development tax credit carryforwards Deferred Tax Assets, Tax Credit Carryforwards, Research Prepayment fee in second year Debt Instrument, Prepayment Rate Two Represents the prepayment rate if prepayment occurs in second year. Company matching contribution Defined Contribution Plan, Cost Statistical Measurement [Axis] Statistical Measurement [Axis] Leasehold improvements Leasehold Improvements [Member] Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Disposal Group Name [Axis] Disposal Group Name [Axis] Accrued contract termination costs Accrued Contract Termination Costs, Current Accrued Contract Termination Costs, Current Restricted cash for the benefit of its leased properties Restricted Cash For The Benefit Of Landlord a Equity Components [Axis] Equity Components [Axis] Scenario [Domain] Scenario [Domain] Recurring Fair Value, Recurring [Member] Options exercisable (in dollars per share Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price Comprehensive Loss Comprehensive Income, Policy [Policy Text Block] Segment Information Segment Reporting, Policy [Policy Text Block] Vesting of restricted stock units APIC, Share-Based Payment Arrangement, Restricted Stock Unit, Increase for Cost Recognition Document Fiscal Year Focus Document Fiscal Year Focus Cash flows from operating activities: Net Cash Provided by (Used in) Operating Activities [Abstract] Statement Statement [Line Items] Disposal group, including discontinued operation, consideration Disposal Group, Including Discontinued Operation, Consideration Unvested restricted common stock beginning of period (in shares) Unvested restricted common stock end of period (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number Deferred Offering Costs Deferred Charges, Policy [Policy Text Block] Total other income (expense), net Nonoperating Income (Expense) Variable Rate [Domain] Variable Rate [Domain] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Operating lease, right-of-use-asset Operating Lease, Right-of-Use Asset Accumulated other comprehensive income (loss) AOCI Attributable to Parent [Member] Impairment of Long-Lived Assets, Assets Held for Sale Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Auditor Firm ID Auditor Firm ID Deferred tax liabilities: Deferred Tax Liabilities, Gross [Abstract] Initial annual base rent Operating Lease, Expense Vested and expected to vest (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price Type of Restructuring [Domain] Type of Restructuring [Domain] Document Transition Report Document Transition Report Local Phone Number Local Phone Number Offering Offering Represents information related to an unwritten public offering. Section 162(m) compensation deduction limitation Effective Income Tax Rate Reconciliation, Tax Expense (Benefit), Share-Based Payment Arrangement, Percent 2022 Strategic Restructuring Plan 2022 Strategic Restructuring Plan [Member] 2022 Strategic Restructuring Plan Schedule of stock option activity Share-Based Payment Arrangement, Option, Activity [Table Text Block] Loss from operations Operating Income (Loss) License costs Other Cost and Expense, Operating Federal operating loss carryforwards Deferred Tax Assets, Operating Loss Carryforwards, Domestic Recently Adopted Accounting Pronouncements New Accounting Pronouncements, Policy [Policy Text Block] Offering costs included in accounts payable and accrued expenses Offering Costs And Issuance Costs Included In Accounts Payable And Accrued Expenses The amount represents the offering costs and issuance costs included in accounts payable and accrued expenses Stock‑based compensation expense Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost Number of leases Number of Operating Leases Number of non cancellable operating lease contracts. Summary of property plant and equipment Public Utility Property, Plant, and Equipment [Table Text Block] Prepaid expenses and other current assets Increase (Decrease) in Prepaid Expense and Other Assets Accrued expenses Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities State and Local Jurisdiction State and Local Jurisdiction [Member] Common stock, shares outstanding (in shares) Common Stock, Shares, Outstanding Aggregate offering price Maximum Aggregate Offering Price Of Stock Maximum amount of aggregate offering price of the Company's common stock sold through Sales Agents under distribution agreement. Long-Lived Tangible Asset [Axis] Long-Lived Tangible Asset [Axis] Adjustments to reconcile net loss to net cash used in operating activities: Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Valuation allowance Valuation allowance as of beginning of year Valuation allowance as of end of year Deferred Tax Assets, Valuation Allowance Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Subsidiary or Equity Method Investee, Sale of Stock by Subsidiary or Equity Investee [Table] Property, Plant and Equipment Property, Plant and Equipment, Policy [Policy Text Block] Number of votes per share Number of Votes Per Share Number of vote entitled to common stock holders per share. Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share 2026 Lessee, Operating Lease, Liability, to be Paid, Year Four Income Statement [Abstract] Income Statement [Abstract] Number of options granted (in shares) Granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Entity Public Float Entity Public Float Additional paid-in capital Additional Paid-in Capital [Member] Document Fiscal Period Focus Document Fiscal Period Focus Restricted cash Restricted cash (non-current) Restricted Cash, Noncurrent Aggregate intrinsic value of stock options exercised Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value Weighted average number of shares outstanding, diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Less: Accumulated depreciation and amortization Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment Long‑term debt, net of current portion Long Term Debt Net Of Current Amount of debt prior to reduction for unamortized (discount) or premium and debt issuance costs classified as noncurrent. Expected term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Prepaid expenses and other current assets Prepaid Expense And Other, Current Amount of asset related to consideration paid in advance and other for costs that provide economic benefits within a future period of one year or the normal operating cycle, if longer. Deferred Tax Asset, Valuation Allowance Activity [Roll Forward] Deferred Tax Asset, Valuation Allowance Activity Common stock, $0.001 par value; 300,000,000 and 150,000,000 shares authorized at December 31, 2022 and December 31, 2021, respectively; 90,387,732 and 90,063,770 shares issued and outstanding at December 31, 2022 and December 31, 2021, respectively Common Stock, Value, Issued Debt Instrument, Name [Domain] Debt Instrument, Name [Domain] At the market offering At the market offering Sale of stock by company under the distribution agreement through the Sales Agents, deemed to be an at the market offering. Deferred tax assets: Deferred Tax Assets, Gross [Abstract] Weighted average grant date fair value- issued (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Schedule of dilutive securities excluded from computations of diluted weighted average shares outstanding Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of financial assets and liabilities measured at fair value on a recurring basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Options exercisable (in dollars) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value Short-term lease cost Short-Term Lease, Cost Property, Plant and Equipment, Net [Abstract] Property, Plant and Equipment, Net [Abstract] Preferred stock, share authorized (in shares) Preferred Stock, Shares Authorized Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash at end of period Cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Current liabilities: Liabilities, Current [Abstract] Proceeds from issuance of common stock upon exercise of stock options and under employee stock purchase plan Proceeds from Stock Options Exercised Common stock, shares issued (in shares) Common Stock, Shares, Issued Vested and expected to vest (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term Number of tranche Debt Instrument, Number Of Tranche Represents the number of tranche. 2018 Equity Incentive Plan 2018 Equity Incentive Plan The information pertaining to 2018 Equity Incentive Plan. Purchases of property, plant and equipment included in accounts payable or accrued expenses Capital Expenditures Incurred but Not yet Paid Percentage of employee's gross pay match Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay Summary of changes in the valuation allowance for deferred tax assets Summary of Valuation Allowance [Table Text Block] Income Statement Location [Domain] Income Statement Location [Domain] Amendment Flag Amendment Flag Net cash provided by investing activities Net Cash Provided by (Used in) Investing Activities Operating lease cost Operating Lease, Cost Principal amount Debt Instrument, Face Amount Investments Investment, Policy [Policy Text Block] Issuance of common stock under employee stock purchase plan Stock Issued During Period, Value, Employee Stock Purchase Plan Comprehensive loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent Operating lease liabilities Increase Decrease, Operating Lease Liabilities The increase (decrease) during the reporting period in the value of operating lease liabilities. Capitalized intellectual property costs Deferred Tax Assets, Capitalized Intellectual Property Costs Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences, Capitalized Intellectual Property Costs. Impairment charges Impairment charges Impairment of Long-Lived Assets to be Disposed of Entity Current Reporting Status Entity Current Reporting Status Federal operating loss carryforwards subject to expiration indefinitely Deferred Tax Assets, Operating Loss Carryforwards, Not Subject to Expiration Amounts paid or otherwise settled during the period Payments for Restructuring Weighted average contractual term and aggregate intrinsic value Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Additional Disclosures [Abstract] Options exercisable (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number Depreciation and amortization expense Depreciation, Depletion and Amortization Employee termination benefits Employee Severance [Member] Federal statutory income tax rate Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent Lease term Lessee, Operating Lease, Term of Contract Issuance of common stock under employee stock purchase plan (in shares) Stock Issued During Period, Shares, Employee Stock Purchase Plans Counterparty Name [Axis] Counterparty Name [Axis] Outstanding at beginning of period (in shares) Outstanding at end of period (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number Debt discount Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net Stock‑based compensation expense Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-Based Payment Arrangement, Percent Accrued Expenses and Other Current Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code State taxes, net of federal benefit Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent Collaborative Arrangements and Non-collaborative Arrangement Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] WIBR WIBR Represents the information pertaining to Whitehead Institute for Biomedical Research. Property, plant and equipment, net Property, plant and equipment, net Property, Plant and Equipment, Net Cash paid for leases Operating Lease, Payments Repayments of long-term debt Repayments of Long-Term Debt Operating leases: Assets and Liabilities, Lessee [Abstract] Share-based Payment Arrangement, Option Share-Based Payment Arrangement, Option [Member] License and Maintenance License and Maintenance [Member] Expected volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Accrued expenses and other current liabilities Accrued expenses and other current liabilities Accrued Expenses And Other Current Liabilities Excluding Current Operating Lease Liabilities Carrying value as of the balance sheet date of obligations incurred and payable, excluding current operating lease liabilities, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Loss on disposal Disposal Group, Not Discontinued Operation, Gain (Loss) on Disposal Issuance of common stock upon exercise of stock options Stock Issued During Period, Value, Stock Options Exercised Restricted stock units forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Other income, net Other Nonoperating Income (Expense) Number of distinct leased spaces Number of Distinct Leased Spaces Number of Distinct Leased Spaces Common stock, share authorized (in shares) Common stock, authorized (in shares) Common Stock, Shares Authorized Shares authorized Aggregate Stock, Shares Authorized The maximum number of shares permitted to be issued by an entity's charter and bylaws. Total operating expenses Operating Expenses Maximum Maximum [Member] Depreciation and other Deferred Tax Liabilities Depreciation and Other The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation Restricted Cash Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Cash and cash equivalents Cash and Cash Equivalents, at Carrying Value Total current assets Assets, Current Entity Small Business Entity Small Business Other Commitments [Table] Other Commitments [Table] Balances at beginning of period (in shares) Balances at end of period (in shares) Shares, Outstanding Measurement Frequency [Domain] Measurement Frequency [Domain] Equity Stockholders' Equity Note Disclosure [Text Block] Restricted cash Restricted Cash Operating Loss Carryforwards [Table] Operating Loss Carryforwards [Table] Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Unrecognized compensation cost Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount Accrued external research and development expenses Accrued Research and Development, Current Carrying value as of the balance sheet date of obligations incurred through that date and payable for research and development expenses. Number of shares Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding [Roll Forward] Property, Plant and Equipment, Net and Assets Held for Sale Property, Plant and Equipment Disclosure [Text Block] Depreciation Deferred Tax Assets, Depreciation Deferred Tax Assets, Depreciation Sublease income Sublease Income Outstanding at the beginning (in dollars) Outstanding at the end (in dollars) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value Long-Lived Tangible Asset [Domain] Long-Lived Tangible Asset [Domain] Impairment of property, plant and equipment Impairment Of Property Plant And Equipment [Member] Impairment Of Property Plant And Equipment Title of 12(b) Security Title of 12(b) Security Nature of the Business and Basis of Presentation Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Sales and maturities of investments Proceeds from Sale, Maturity and Collection of Investments Payables and Accruals [Abstract] Payables and Accruals [Abstract] Debt Instrument [Line Items] Debt Instrument [Line Items] Payments of debt issuance costs Payments of Debt Issuance Costs Operating lease liability Operating Lease, Liability Stock-Based Compensation Share-Based Payment Arrangement [Policy Text Block] Liabilities and Stockholders' Equity Liabilities and Equity [Abstract] Aggregate milestone payments Aggregate Milestone Payments, Achievement of Specified Milestones The aggregate milestone payments to be made on achieving of specific . Granted (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] Accounts payable Accounts Payable, Current Restructuring charges Restructuring Charges Comprehensive loss: Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Income Tax Authority [Axis] Income Tax Authority [Axis] Other assets Increase (Decrease) in Other Operating Assets Vested and expected to vest (in dollars) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value Auditor Location Auditor Location Entity Filer Category Entity Filer Category Weighted average number of shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Deposit received for assets held for sale Deposit For Assets Held-For-Sale, Current Deposit For Assets Held-For-Sale, Current Operating lease liabilities Deferred Tax Assets, Operating Lease Liabilities Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from operating lease liabilities. Stock-based compensation expense Share-Based Payment Arrangement, Expense Commitments and contingencies (see Note 10) Commitments and Contingencies Security Exchange Name Security Exchange Name Outstanding at the beginning (in dollars per share) Outstanding at the end (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Operating lease, termination payment Operating Lease, Termination Payment Operating Lease, Termination Payment Fair value of financial assets and liabilities Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2022 and December 31, 2021; no shares issued or outstanding at December 31, 2022 and December 31, 2021 Preferred Stock, Value, Issued Assets held for sale Disposal Group, Including Discontinued Operation, Assets, Current Restricted cash, current Restricted Cash, Current Restricted Stock Restricted Stock [Member] Marketable securities Debt Securities, Available-for-Sale, Fair Value to Amortized Cost, after Allowance for Credit Loss [Abstract] Property, Plant and Equipment, Net Property, Plant and Equipment [Line Items] Schedule of long term debt Schedule of Debt [Table Text Block] General and administrative expenses General and Administrative Expense [Member] Entity Well-known Seasoned Issuer Entity Well-known Seasoned Issuer Employer matching contribution (as a percent) Defined Contribution Plan, Employer Matching Contribution, Percent of Match Cover [Abstract] Cover [Abstract] Schedule of Long-term Debt Instruments [Table] Schedule of Long-Term Debt Instruments [Table] Leases Lessee, Leases [Policy Text Block] Level 3 Fair Value, Inputs, Level 3 [Member] Entity Voluntary Filers Entity Voluntary Filers Depreciation and amortization expense Depreciation, Depletion and Amortization, Nonproduction Restructuring and Related Activities [Abstract] Stock-Based Compensation Share-Based Payment Arrangement [Text Block] Other Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent Schedule of allocation of share based compensation Share-Based Payment Arrangement, Cost by Plan [Table Text Block] Forecast Forecast [Member] Risk-free interest rate Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Total liabilities and stockholders' equity Liabilities and Equity Net deferred tax assets Schedule of Deferred Tax Assets and Liabilities [Table Text Block] Related Party [Axis] Related Party [Axis] Land Land [Member] Stock-based compensation, fair value Share-based Compensation Arrangement by Share-based Payment Award, Options, Grant Date Fair Value The amount represents the value of share-based compensation arrangement by share-based payment award, options, grant date fair value. Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Total deferred tax assets Deferred Tax Assets, Gross Disposal Group Name [Domain] Disposal Group Name [Domain] Stock-based compensation expense Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Level 2 Fair Value, Inputs, Level 2 [Member] Purchases of investments Payments to Acquire Investments Current Fiscal Year End Date Current Fiscal Year End Date Accrued interest or penalties Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued Less: imputed interest Lessee, Operating Lease, Liability, Undiscounted Excess Amount Disposal group, including discontinued operation, assets Disposal Group, Including Discontinued Operation, Assets 2022 Restructuring Plan 2022 Restructuring Plan [Member] 2022 Restructuring Plan Net loss per share, diluted (in dollars per share) Earnings Per Share, Diluted Sale of Stock [Domain] Sale of Stock [Domain] Proceeds from sale of property, plant and equipment Proceeds from Sale of Property, Plant, and Equipment Vesting period Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period Payments of offering costs Payments of Stock Issuance Costs Impairment charges Gain (Loss) on Disposition of Property Plant Equipment Stock-based compensation expense APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Total current liabilities Liabilities, Current 2024 Lessee, Operating Lease, Liability, to be Paid, Year Two Restructuring Cost and Reserve [Line Items] Restructuring Cost and Reserve [Line Items] Number of expiration period Number of Expiration Dates Represents the number of expiration dates. Federal operating loss carryforwards subject to expiration Deferred Tax Assets, Operating Loss Carryforwards, Subject to Expiration Other income (expense): Nonoperating Income (Expense) [Abstract] Entity Address, Address Line Three Entity Address, Address Line Three Schedule of minimum lease payments under the Company's operating leases Lessee, Operating Lease, Liability, Maturity [Table Text Block] Entity Address, Address Line Two Entity Address, Address Line Two Entity Address, Address Line One Entity Address, Address Line One Income Tax Authority [Domain] Income Tax Authority [Domain] Base rent incremental (as a percentage) Operating Lease, Base Rent incremental Percentage Base rent increase during the initial term in percentage annually on the anniversary of the commencement date. Operating lease, right-of-use-asset Increase Decrease, Operating Lease, Right Of Use Asset The increase (decrease) during the reporting period in the value of operating lease, right-of-use-asset. Unrealized losses on investments Unrealized Gain (Loss) on Investments Product and Service [Axis] Product and Service [Axis] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Nature of the business and basis of presentation Subsidiary, Sale of Stock [Line Items] Subsidiary, Sale of Stock [Line Items] Interest expense Interest Expense Research and Manufacturing Contract Costs and Accruals Research and Manufacturing Contract Costs and Accruals [Policy Text Block] Disclosure of accounting policy for research and manufacturing contract costs and accruals. Unrealized losses on investments, net of tax of $0 OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Operating lease assets Deferred Tax Liabilities, Leasing Arrangements Remeasurement of operating lease liabilities and right-of-use assets due to lease modification Proceeds From Stock Options Exercised In Other Current Assets Amount of cash inflow from exercise of option in other current assets under share-based payment arrangement. Vesting of restricted stock units (in shares) Restricted stock units vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Entity Tax Identification Number Entity Tax Identification Number Total number of shares of common stock authorized to issue (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized Lease asset derecognized upon lease cancellation Lease Asset Derecognized Upon Lease Cancellation Amount of decrease in right-of-use asset upon cancellation of lease. Total deferred tax liabilities Deferred Tax Liabilities, Gross Schedule of reconciliation of the U.S. federal statutory income tax rate to the Company's effective income tax Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Schedule of Restructuring Reserve by Type of Cost Schedule of Restructuring Reserve by Type of Cost [Table Text Block] Restructuring and Related Costs Restructuring and Related Costs [Table Text Block] Entity Central Index Key Entity Central Index Key Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Interest income Investment Income, Interest Measurement Frequency [Axis] Measurement Frequency [Axis] Research and Development Costs Research and Development Expense, Policy [Policy Text Block] Weighted Average Grant Date Fair Value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Deferred Financing Costs Deferred Financing Costs [policy Text Block] Disclosure of accounting policy for deferred financing costs. Increase in gross deferred tax assets, before valuation allowance "Deferred Tax Asset, Increase (Decrease), Amount " The amount of increase (decrease) in gross deferred tax assets, before valuation allowance. Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table] Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table] Concentrations of Credit Risk and of Significant Suppliers Concentration Risk, Credit Risk, Policy [Policy Text Block] Other Other Accrued Liabilities, Current City Area Code City Area Code General and administrative General and Administrative Expense Assets Assets [Abstract] Loan Agreement Loan Agreement [Member] Loan Agreement Commitments and Contingencies Other Commitments [Line Items] Statement of Stockholders' Equity [Abstract] Statement of Stockholders' Equity [Abstract] Sale of Stock [Axis] Sale of Stock [Axis] Patent Costs Patent Costs [Policy Text Block] Disclosure of accounting policy for patent costs. Cash flows from financing activities: Net Cash Provided by (Used in) Financing Activities [Abstract] Proceeds from underwritten public offering of common stock, net of commissions and underwriting discounts Net proceeds after deducting underwriting discounts and commissions Proceeds from Issuance Initial Public Offering Net Income (Loss) per Share Earnings Per Share, Policy [Policy Text Block] Supplemental disclosure of non-cash investing and financing information: Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Stock-based compensation expense Share-Based Payment Arrangement, Noncash Expense Weighted average grant-date fair value (per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value Variable Rate [Axis] Variable Rate [Axis] Other long-term liabilities Other Liabilities, Noncurrent Disposal Group Classification [Domain] Disposal Group Classification [Domain] Purchases of property, plant and equipment Payments to Acquire Property, Plant, and Equipment Construction-in-progress Asset under Construction [Member] Research and development expenses Research and Development Expense [Member] Schedule of calculation of basic and diluted net loss per share attributable to common stockholders Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Lease assets obtained in exchange for new operating lease liabilities Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Restructuring and related cost, number of positions eliminated, period percent Restructuring and Related Cost, Number of Positions Eliminated, Period Percent Accrued manufacturing facility expenses Accrued Manufacturing Facility Expenses Current Carrying value as of the balance sheet date of obligations incurred through that date and payable for manufacturing facility expenses.