CONSOLIDATED STATEMENTS STOCKHOLDERS EQUITY - USD ($)
$ in Thousands
Total
Common stock
Additional paid-in capital
Accumulated other comprehensive income (loss)
Accumulated deficit
Balances at beginning of period (in shares) at Dec. 31, 2019   80,016,245      
Balances at beginning of period at Dec. 31, 2019 $ 274,213 $ 80 $ 586,798 $ 75 $ (312,740)
Issuance of common stock upon exercise of stock options (in shares)   1,037,406      
Issuance of common stock upon exercise of stock options 1,484 $ 1 1,483    
Stock-based compensation expense 33,665   33,665    
Unrealized losses on investments (71)     (71)  
Issuance of common stock under employee stock purchase plan (in shares)   0      
Net loss (167,731)       (167,731)
Balances at end of period (in shares) at Dec. 31, 2020   81,053,651      
Balances at end of period at Dec. 31, 2020 141,560 $ 81 621,946 4 (480,471)
Issuance of common stock upon exercise of stock options (in shares)   1,933,523      
Issuance of common stock upon exercise of stock options 10,685 $ 2 10,683    
Stock-based compensation expense 35,610   35,610    
Vesting of restricted stock units (in shares)   153,600      
Vesting of restricted stock units 0        
Unrealized losses on investments (4)     (4)  
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs (in shares)   6,896,552      
Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs of $800 187,200 $ 7 187,193    
Issuance of common stock under employee stock purchase plan (in shares)   26,444      
Issuance of common stock under employee stock purchase plan 278   278    
Net loss (196,547)       (196,547)
Balances at end of period (in shares) at Dec. 31, 2021   90,063,770      
Balances at end of period at Dec. 31, 2021 178,782 $ 90 855,710 0 (677,018)
Issuance of common stock upon exercise of stock options (in shares)   42,228      
Issuance of common stock upon exercise of stock options 98   98    
Stock-based compensation expense 15,783   15,783    
Vesting of restricted stock units (in shares)   137,828      
Vesting of restricted stock units 0        
Issuance of common stock under employee stock purchase plan (in shares)   143,906      
Issuance of common stock under employee stock purchase plan 134   134    
Net loss (179,666)       (179,666)
Balances at end of period (in shares) at Dec. 31, 2022   90,387,732      
Balances at end of period at Dec. 31, 2022 $ 15,131 $ 90 $ 871,725 $ 0 $ (856,684)