CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands |
12 Months Ended |
Dec. 31, 2022 |
Dec. 31, 2021 |
Dec. 31, 2020 |
| Income Statement [Abstract] |
|
|
|
| Revenue |
$ 0
|
$ 0
|
$ 0
|
| Operating expenses: |
|
|
|
| Research and development |
96,414
|
141,587
|
116,107
|
| General and administrative |
30,835
|
53,029
|
50,341
|
| Restructuring and impairment charges |
51,197
|
0
|
0
|
| Total operating expenses |
178,446
|
194,616
|
166,448
|
| Loss from operations |
(178,446)
|
(194,616)
|
(166,448)
|
| Other income (expense): |
|
|
|
| Interest income |
819
|
91
|
1,760
|
| Interest expense |
(3,863)
|
(6,434)
|
(4,185)
|
| Other income, net |
1,824
|
4,412
|
1,142
|
| Total other income (expense), net |
(1,220)
|
(1,931)
|
(1,283)
|
| Net loss |
$ (179,666)
|
$ (196,547)
|
$ (167,731)
|
| Net loss per share, diluted (in dollars per share) |
$ (1.99)
|
$ (2.23)
|
$ (2.08)
|
| Net loss per share, basic (in dollars per share) |
$ (1.99)
|
$ (2.23)
|
$ (2.08)
|
| Weighted average number of shares outstanding, diluted (in shares) |
90,305,463
|
87,950,440
|
80,624,608
|
| Weighted average number of shares outstanding, basic (in shares) |
90,305,463
|
87,950,440
|
80,624,608
|
| Comprehensive loss: |
|
|
|
| Net loss |
$ (179,666)
|
$ (196,547)
|
$ (167,731)
|
| Other comprehensive income (loss): |
|
|
|
| Unrealized losses on investments, net of tax of $0 |
0
|
(4)
|
(71)
|
| Comprehensive loss |
$ (179,666)
|
$ (196,551)
|
$ (167,802)
|