Cover Page - USD ($)
$ in Millions
 12 Months Ended
Dec. 31, 2022
Jan. 31, 2023
Jun. 30, 2022
Cover [Abstract]      
Document Type 10-K    
Document Annual Report true    
Document Period End Date Dec. 31, 2022    
Current Fiscal Year End Date --12-31    
Document Transition Report false    
Entity File Number 001-38586    
Entity Registrant Name RUBIUS THERAPEUTICS, INC.    
Entity Incorporation, State or Country Code DE    
Entity Tax Identification Number 46-2688109    
Entity Address, Address Line One c/o Verdolino & Lowey, P.C.    
Entity Address, Address Line Two 124 Washington Street,    
Entity Address, Address Line Three Suite 101    
Entity Address, City or Town Foxborough,    
Entity Address, State or Province MA    
Entity Address, Postal Zip Code 02035    
City Area Code (508)    
Local Phone Number 543-1720    
Title of 12(b) Security Common Stock, par value $0.001 per share    
Trading Symbol RUBY    
Security Exchange Name NASDAQ    
Entity Well-known Seasoned Issuer No    
Entity Voluntary Filers No    
Entity Current Reporting Status Yes    
Entity Interactive Data Current Yes    
Entity Filer Category Non-accelerated Filer    
Entity Small Business true    
Entity Emerging Growth Company false    
Entity Shell Company false    
Entity Public Float     $ 28.4
Entity Common Stock, Shares Outstanding   90,397,732  
Document Fiscal Year Focus 2022    
Document Fiscal Period Focus FY    
Entity Central Index Key 0001709401    
Amendment Flag false