Document and Entity Information Document Information [Table] Document Information [Line Items] Auditor Name Auditor Firm ID Auditor Location Document Type Document Annual Report Document Transition Report Document Period End Date Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company ICFR Auditor Attestation Flag Entity Common Stock, Shares Outstanding Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Entity Central Index Key Amendment Flag Entity Well-known Seasoned Issuer Entity Public Float Entity Voluntary Filers CONDENSED CONSOLIDATED BALANCE SHEETS Statement [Table] Statement [Line Items] Statement Assets [Abstract] Assets Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Short-term Investments Investments Investments Amount of asset related to consideration paid in advance and other for costs that provide economic benefits within a future period of one year or the normal operating cycle, if longer. Prepaid Expense And Other, Current Prepaid expenses and other current assets Assets, Current Total current assets Operating Lease, Right-of-Use Asset Operating lease, right-of-use-asset Property, Plant and Equipment, Net Property, plant and equipment, net Property, plant and equipment, net Restricted Cash, Noncurrent Restricted cash Restricted cash (non-current) Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and Stockholders' Equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Carrying value as of the balance sheet date of obligations incurred and payable, excluding current operating lease liabilities, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Expenses And Other Current Liabilities Excluding Current Operating Lease Liabilities Accrued expenses and other current liabilities Accrued expenses and other current liabilities Operating Lease, Liability, Current Operating lease liabilities Liabilities, Current Total current liabilities Long-term Debt, Excluding Current Maturities Long-term debt, net of discount Longterm debt, net of discount and current portion Other Liabilities, Noncurrent Other long-term liabilities Operating Lease, Liability, Noncurrent Operating lease liabilities, net of current portion Liabilities Total liabilities Commitments and Contingencies. Commitments and contingencies (see Note 10) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.001 par value; 10,000,000 shares authorized at December 31, 2021 and December 31, 2020; no shares issued or outstanding at December 31, 2021 and December 31, 2020 Common Stock, Value, Issued Common stock, $0.001 par value; 150,000,000 shares authorized at December 31, 2021 and December 31, 2020; 90,063,770 and 81,053,651 shares issued and outstanding at December 31, 2021 and December 31, 2020, respectively Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Balances at End of period Balances at Beginning of period Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, share authorized (in shares) Preferred Stock, Shares Issued Preferred stock, shares issued (in shares) Preferred Stock, Shares Outstanding Preferred stock, shares outstanding (in shares) Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, share authorized (in shares) Common stock, authorized (in shares) Common Stock, Shares, Issued Common stock, shares issued (in shares) Common Stock, Shares, Outstanding Common stock, shares outstanding (in shares) CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS Operating Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Nonoperating Income (Expense) [Abstract] Other income (expense): Investment Income, Interest Interest income Interest Expense Interest expense Other Nonoperating Income (Expense) Other income, net Nonoperating Income (Expense) Total other income (expense), net Net Income (Loss) Attributable to Parent Net Loss Net loss Net loss Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract] Comprehensive loss: Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income (loss): Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax Unrealized (losses) on investments, net of tax of $0 Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive loss Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, Tax Unrealized gains (losses) on investments, tax CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY Equity Components [Axis] Equity Component [Domain] Common stock Additional paid-in capital Accumulated other comprehensive income Accumulated deficit Cumulative Effect, Period of Adoption [Axis] Cumulative Effect, Period of Adoption [Domain] Adjustments Shares, Outstanding Balances at End of period (in shares) Balances at Beginning of period (in shares) Stock Issued During Period, Value, New Issues Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs of $800 Stock Issued During Period, Shares, New Issues Shares issued (in shares) Issuance of common stock from public offering, net of commissions, underwriting discounts and offering costs (in shares) Stock Issued During Period, Value, Stock Options Exercised Issuance of common stock upon exercise of stock options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised Issuance of common stock upon exercise of stock options (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Issuance of common stock under employee stock purchase plan Stock Issued During Period, Shares, Employee Stock Purchase Plans Issuance of common stock under employee stock purchase plan (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Vested Vesting of restricted stock units The amount of stock issued during period restricted common stock exercise of stock options. Stock Issued During Period Value Restricted Common Stock Exercise Of Stock Options Issuance of restricted common stock upon early exercise of stock options Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition Stock-based compensation expense Stock Repurchased During Period, Value Repurchase of unvested restricted common stock Stock Repurchased During Period, Shares Repurchase of unvested restricted common stock (in shares) Adjustments to Additional Paid in Capital, Share-based Compensation, Restricted Stock Unit or Restricted Stock Award, Requisite Service Period Recognition Vesting of restricted common stock Unrealized Gain (Loss) on Investments Unrealized gains (losses) on investments Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Net of commissions, underwriting discounts and offering costs CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS Cash flows from operating activities: Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Share-based Compensation Stock-based compensation expense Depreciation, Depletion and Amortization Depreciation and amortization expense Investment Income, Net, Amortization of Discount and Premium Amortization (accretion) of premium (discount) on investments Gain (Loss) on Disposition of Property Plant Equipment Loss on disposal of property and equipment Non-Cash Interest Expenses Non-cash interest expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets The increase (decrease) during the reporting period in the value of operating lease, right-of-use-asset. Increase Decrease, Operating Lease, Right Of Use Asset Operating lease, right-of-use-asset Other assets Other assets Increase (Decrease) in Accounts Payable Accounts payable The increase (decrease) during the reporting period in the amounts of accrued expenses and other current liabilities. Increase (Decrease) in Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities Increase (Decrease) in Other Noncurrent Liabilities Other long-term liabilities The increase (decrease) during the reporting period in the value of operating lease liabilities. Increase Decrease, Operating Lease Liabilities Operating lease liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities [Abstract] Cash flows from investing activities: Payments to Acquire Property, Plant, and Equipment Purchases of property, plant and equipment Payments to Acquire Investments Purchases of investments Proceeds from Sale, Maturity and Collection of Investments Sales and maturities of investments Net Cash Provided by (Used in) Investing Activities Net cash provided by (used in) investing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Cash flows from financing activities: Proceeds from Issuance Initial Public Offering Net proceeds after deducting underwriting discounts and commissions Proceeds from underwritten public offering of common stock, net of commissions and underwriting discounts Payments of Stock Issuance Costs Payments of offering costs Payments of Debt Issuance Costs Payments of debt issuance costs Payments for Repurchase of Common Stock Repurchase of unvested restricted common stock Proceeds from (Repayments of) Secured Debt Proceeds from borrowings under loan and security agreement Proceeds from Stock Options Exercised Proceeds from issuance of common stock upon exercise of stock options Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase (decrease) in cash, cash equivalents and restricted cash Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash, cash equivalents and restricted cash at end of period Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash Supplemental Cash Flow Information [Abstract] Supplemental cash flow information: Interest Paid, Excluding Capitalized Interest, Operating Activities Cash paid for interest Operating Lease, Payments Cash paid for leases Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract] Supplemental disclosure of non-cash investing and financing information: Capital Expenditures Incurred but Not yet Paid Purchases of property, plant and equipment included in accounts payable or accrued expenses The amount represents the offering costs and issuance costs included in accounts payable and accrued expenses Offering Costs And Issuance Costs Included In Accounts Payable And Accrued Expenses Offering costs and issuance costs included in accounts payable and accrued expenses Right-of-Use Asset Obtained in Exchange for Operating Lease Liability Lease assets obtained in exchange for new operating lease liabilities Amount of cash inflow from exercise of option in other current assets under share-based payment arrangement. Proceeds From Stock Options Exercised In Other Current Assets Proceeds from issuance of common stock upon exercise of stock options in other current assets Amount of decrease in right-of-use asset upon cancellation of lease. Lease Asset Derecognized Upon Lease Cancellation Lease asset derecognized upon lease cancellation Nature of the Business and Basis of Presentation Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Nature of the Business and Basis of Presentation Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Investments and Fair Value of Financial Assets and Liabilities Fair Value Disclosures [Text Block] Investments and Fair Value of Financial Assets and Liabilities Property, Plant and Equipment, Net. Property, Plant and Equipment Disclosure [Text Block] Property, Plant and Equipment, Net Accrued Expenses and Other Current Liabilities Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block] Accrued Expenses and Other Current Liabilities Debt Debt Disclosure [Text Block] Debt Equity Stockholders' Equity Note Disclosure [Text Block] Equity Stock-Based Compensation Disclosure of Compensation Related Costs, Share-based Payments [Text Block] Stock-Based Compensation Income Taxes Income Tax Disclosure [Text Block] Income Taxes Commitments and Contingencies Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Leases Lessee, Operating Leases [Text Block] Leases Net Loss per Share Earnings Per Share [Text Block] Net Loss per Share Use of Estimates, Policy [Policy Text Block] Use of Estimates Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentrations of Credit Risk and of Significant Suppliers Deferred Charges, Policy [Policy Text Block] Deferred Offering Costs Disclosure of accounting policy for deferred financing costs. Deferred Financing Costs [policy Text Block] Deferred Financing Costs Cash and Cash Equivalents, Policy [Policy Text Block] Cash Equivalents Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block] Restricted Cash Property, Plant and Equipment, Policy [Policy Text Block] Property, Plant and Equipment Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block] Impairment of Long Lived Assets