<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001793313</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001564406</issuerCik>
      <issuerName>Oak Street Health, Inc.</issuerName>
      <secFileNumber>001-39427</secFileNumber>
      <issuerAddress>
        <com:street1>30 W. MONROE ST., STE. 1200</com:street1>
        <com:city>CHICAGO</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60603</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>312-773-3374</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>PRICE GEOFFREY M</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Fidelity Brokerage Services LLC</name>
        <address>
          <com:street1>900 Salem Street</com:street1>
          <com:city>Smithfield</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02917</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>50000</noOfUnitsSold>
      <aggregateMarketValue>1785500.00</aggregateMarketValue>
      <noOfUnitsOutstanding>243999366</noOfUnitsOutstanding>
      <approxSaleDate>03/21/2023</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>03/21/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Granted - 08/05/2020</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>50000</amountOfSecuritiesAcquired>
      <paymentDate>03/21/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>01/10/2023</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1486835.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/07/2023</saleDate>
      <amountOfSecuritiesSold>400000</amountOfSecuritiesSold>
      <grossProceeds>13629508.53</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/10/2023</saleDate>
      <amountOfSecuritiesSold>7413</amountOfSecuritiesSold>
      <grossProceeds>263902.80</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/21/2023</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1766150.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/22/2023</saleDate>
      <amountOfSecuritiesSold>122985</amountOfSecuritiesSold>
      <grossProceeds>4378958.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>02/23/2023</saleDate>
      <amountOfSecuritiesSold>7728</amountOfSecuritiesSold>
      <grossProceeds>274227.31</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/07/2023</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>1776881.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/15/2023</saleDate>
      <amountOfSecuritiesSold>1831</amountOfSecuritiesSold>
      <grossProceeds>65183.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/16/2023</saleDate>
      <amountOfSecuritiesSold>79858</amountOfSecuritiesSold>
      <grossProceeds>2844238.50</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoffrey Price</name>
        <address>
          <com:street1>30 W. Monroe Street</com:street1>
          <com:street2>Suite 1200</com:street2>
          <com:city>Chicago</com:city>
          <com:stateOrCountry>IL</com:stateOrCountry>
          <com:zipCode>60603</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>03/17/2023</saleDate>
      <amountOfSecuritiesSold>37913</amountOfSecuritiesSold>
      <grossProceeds>1350692.33</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>03/21/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/08/2022</planAdoptionDate>
      </planAdoptionDates>
      <signature>/s/Wade Moss, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for  Geoffrey Price</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
