Property and Equipment - Schedule of Property and Equipment (Detail) - USD ($)
$ in Thousands
Dec. 31, 2015
Dec. 31, 2014
Property, Plant and Equipment [Line Items]    
Total property and equipment $ 13,202 $ 11,253
less: accumulated depreciation (7,989) (6,375)
Property and equipment, net 5,213 4,878
Office Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Total property and equipment 539 467
Laboratory Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Total property and equipment 4,337 2,978
Leasehold Improvements [Member]    
Property, Plant and Equipment [Line Items]    
Total property and equipment 7,683 7,503
Construction in Progress [Member]    
Property, Plant and Equipment [Line Items]    
Total property and equipment 547 270
Software [Member]    
Property, Plant and Equipment [Line Items]    
Total property and equipment $ 96 $ 35