Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Summary of Stock Option Activity Under the 2012 and 2013 Plans

Stock option activity under the 2012 and 2013 plans is summarized as follows:

 

     Number
of Options
    Weighted-
Average
Exercise
Price
     Weighted-
Average
Remaining
Contractual
Term
(in years)
     Aggregate
Intrinsic
Value
(in thousands)
 

Outstanding at December 31, 2014

     537,683      $ 6.19         8.9       $ 2,488   

Granted

     914,722        7.74         

Exercised

     (53,458     0.76         

Cancelled

     (176,180     8.13         
  

 

 

   

 

 

    

 

 

    

 

 

 

Outstanding at December 31, 2015

     1,222,767      $ 7.31         9.0       $ (4,679
  

 

 

   

 

 

    

 

 

    

 

 

 

Vested and expected to vest at December 31, 2014

     451,153      $ 5.83         8.9       $ 2,247   
  

 

 

   

 

 

    

 

 

    

 

 

 

Vested and expected to vest at December 31, 2015

     1,133,925      $ 7.29         9.0       $ (4,293
  

 

 

   

 

 

    

 

 

    

 

 

 

Exercisable at December 31, 2014

     139,798      $ 1.84         8.1       $ 1,239   
  

 

 

   

 

 

    

 

 

    

 

 

 

Exercisable at December 31, 2015

     318,733      $ 4.60         7.6       $ (351
  

 

 

   

 

 

    

 

 

    

 

 

 
Additional Information about Stock Option Activity

Additional information about the Company’s stock option activity is as follows:

 

     Years Ended December 31,  
         2015              2014      

Weighted-average grant date fair value per share of employee option grants within the year

   $ 4.08       $ 6.70   

Cash received upon exercise of options

     39         26   
Schedule of Restricted Stock Awards Under the 2012 and 2013 Plans

Restricted stock awards under the 2012 and 2013 plans are summarized as follows:

 

     Number of
Shares
     Weighted Average
Grant Date Fair
Value
 

Unvested at December 31, 2014

     8,493       $ 1.04   

Vesting of restricted stock

     (3,303      1.00   
  

 

 

    

 

 

 

Unvested at December 31, 2015

     5,190       $ 1.07   
  

 

 

    

 

 

 
Summary of Stock-Based Compensation

Stock-based compensation is as follows:

 

     Years Ended December 31,  
         2015              2014      

Research and development

   $ 451       $ 181   

General and administrative

     777         366   
  

 

 

    

 

 

 

Total stock-based compensation expense

   $ 1,228       $ 547   
  

 

 

    

 

 

 

Summary of Weighted-Average Assumptions Used in the Black-Scholes Option Pricing Model to Determine the Fair Value of the Employee Stock Option Grants

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the employee stock option grants were as follows:

 

     Years Ended December 31,  
         2015             2014      

Risk-free interest rate

     1.68     1.83

Expected volatility

     62.6     104.5

Expected term (in years)

     6.04        6.08   

Expected dividend yield

     0.0     0.0
Summary of Weighted-Average Assumptions Used in the Black-Scholes Option Pricing Model to Determine the Fair Value of the Non-Employee Stock Option Grants

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the non-employee stock option grants were as follows:

 

     Years Ended December 31,  
         2015             2014      

Risk-free interest rate

     1.79     0.89

Expected volatility

     63.2     99.4

Expected term (in years)

     6.16        2.47   

Expected dividend yield

     0.0     0.0