Operating Expenses by Nature - Schedule of Operating Expenses by Nature (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Expense By Nature [Abstract]      
External research and development costs $ 38,287 $ 51,803 $ 70,531
Staff costs (note 16) 18,788 19,643 24,556
Professional fees 12,175 3,994 7,072
Rents 60 22 21
Travel expenses 229 156 1,398
Patent registration costs 887 813 882
Depreciation 736 721 737
Other 3,466 2,566 1,914
Total operating expenses by nature $ 74,627 $ 79,718 $ 107,111