Consolidated Statements of Cash Flows - USD ($)
$ in Thousands |
12 Months Ended |
Dec. 31, 2021 |
Dec. 31, 2020 |
Dec. 31, 2019 |
| Statement Of Cash Flows [Abstract] |
|
|
|
| NET LOSS BEFORE TAX FOR THE YEAR |
$ (58,165)
|
$ (82,932)
|
$ (108,723)
|
| Adjustments for: |
|
|
|
| Depreciation expense |
736
|
721
|
737
|
| Post-employment (benefit) / cost |
(553)
|
492
|
(477)
|
| Share-based compensation expense |
5,843
|
6,506
|
11,884
|
| Income tax paid |
|
(52)
|
(80)
|
| Other operating income |
(20,095)
|
|
|
| Finance expense, net |
3,651
|
3,231
|
1,628
|
| Changes in operating assets and liabilities: |
|
|
|
| Other receivables |
(3,198)
|
326
|
193
|
| Prepaid expenses, deferred costs and other long-term assets |
166
|
(1,029)
|
1,356
|
| Other payables and current liabilities |
(2,223)
|
2,141
|
5,499
|
| Accrued expenses and other long-term liabilities |
3,534
|
(170)
|
(2,628)
|
| NET CASH FLOWS USED IN OPERATING ACTIVITIES |
(70,304)
|
(70,766)
|
(90,611)
|
| Net proceeds from disposal of intangible assets |
22,200
|
|
|
| Payments for plant and equipment |
(14)
|
(5)
|
(46)
|
| Acquisition of a license |
|
|
(5,000)
|
| NET CASH FLOWS FROM (USED IN) INVESTING ACTIVITIES |
22,186
|
(5)
|
(5,046)
|
| Proceeds from issuance of shares |
53,226
|
37,254
|
3,206
|
| Proceeds from the exercise of warrants |
22,117
|
|
|
| Oxford loan repayment |
(26,986)
|
|
|
| Proceeds from issuance of convertible debt |
27,354
|
|
|
| Proceeds from issuance of warrants |
2,646
|
|
|
| Issuance costs related to convertible debt and warrant |
(2,128)
|
|
|
| Proceeds from exercise of stock-options |
|
|
193
|
| Share issuance costs |
(1,959)
|
|
|
| Principal elements of lease payments |
(682)
|
(630)
|
(571)
|
| Interest paid |
(2,484)
|
(2,321)
|
(818)
|
| NET CASH FLOWS FROM FINANCING ACTIVITIES |
71,104
|
32,249
|
26,627
|
| Net (decrease) / increase in cash and cash equivalents |
22,986
|
(38,522)
|
(69,030)
|
| Cash and cash equivalents at January 1, |
31,183
|
69,370
|
138,640
|
| Effects of exchange rate changes on cash and cash equivalents |
565
|
335
|
(240)
|
| Cash and cash equivalents at December 31, |
$ 54,734
|
$ 31,183
|
$ 69,370
|