Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Cash flows from operating activities:    
Net loss $ (11,154) $ (7,109)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 239 390
Stock-based compensation expense 1,421 1,266
Change in common stock warrant value 1,532 (1,457)
Changes in operating assets and liabilities:    
Collaboration receivable 5,255 12,902
Prepaid expenses and other assets (436) 835
Accounts payable (265) 2,317
Accrued clinical and development expenses 2,250 (1,952)
Accrued liabilities 1,016 801
Deferred rent (18) 47
Deferred revenue (3,681) (3,681)
Net cash (used in) provided by operating activities (3,841) 4,359
Cash flows from investing activities:    
Acquisition of property and equipment (38) (24)
Acquisition of marketable securities (32,899) (22,349)
Proceeds from sale of marketable securities 1,997 3,109
Proceeds from maturities of marketable securities 18,939 14,024
Net cash used in investing activities (12,001) (5,240)
Cash flows from financing activities:    
Proceeds from issuance of common stock and warrants, net of offering expenses 28,514 345
Net cash provided by financing activities 28,514 345
Net increase (decrease) in cash and cash equivalents 12,672 (536)
Cash and cash equivalents, beginning of period 8,391 7,279
Cash and cash equivalents, end of period $ 21,063 $ 6,743