Consolidated Statements of Operations and Comprehensive Loss - USD ($)
$ in Thousands |
12 Months Ended |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
| Income Statement [Abstract] |
|
|
|
| Revenue |
$ 0
|
$ 0
|
$ 0
|
| Operating expenses: |
|
|
|
| Research and development |
39,936
|
54,618
|
27,391
|
| General and administrative |
18,289
|
19,195
|
8,141
|
| Total operating expenses |
58,225
|
73,813
|
35,532
|
| Loss from operations |
(58,225)
|
(73,813)
|
(35,532)
|
| Other income (expense): |
|
|
|
| Interest income |
894
|
438
|
28
|
| Interest expense |
(529)
|
(806)
|
(870)
|
| Foreign currency transaction gains (losses), net |
(18)
|
(105)
|
(104)
|
| Total other income (expense), net |
347
|
(473)
|
(946)
|
| Net loss |
(57,878)
|
(74,286)
|
(36,478)
|
| Accretion of redeemable convertible preferred stock to redemption value |
|
|
(92)
|
| Net loss attributable to common stockholders |
$ (57,878)
|
$ (74,286)
|
$ (36,570)
|
| Net loss per share attributable to common stockholders, basic and diluted |
$ (2.12)
|
$ (2.78)
|
$ (3.00)
|
| Weighted average common shares outstanding, basic and diluted |
27,297,934
|
26,756,079
|
12,189,155
|
| Comprehensive loss: |
|
|
|
| Net loss |
$ (57,878)
|
$ (74,286)
|
$ (36,478)
|
| Other comprehensive loss: |
|
|
|
| Unrealized gain (loss) on marketable securities |
127
|
(172)
|
(35)
|
| Total other comprehensive loss |
127
|
(172)
|
(35)
|
| Total comprehensive loss |
$ (57,751)
|
$ (74,458)
|
$ (36,513)
|