Restructuring (Tables)
 12 Months Ended
Dec. 31, 2016
Restructuring and Related Activities [Abstract]  
Summary of Restructuring Costs by Category

The following table summarizes the restructuring costs by category for the periods indicated:

 

     Year Ended December 31, 2016  
     (in thousands)  
     Cash      Non-cash      Total  

Research and development

    $ 455      $ 7      $ 462  

General and administrative

      768        173        941  
  

 

 

     

 

 

     

 

 

  
   $ 1,223      $ 180      $ 1,403  
  

 

 

     

 

 

     

 

 

  
Summary of Restructuring Reserve

The following table summarizes the restructuring reserve for the periods indicated:

 

     Year Ended
December 31, 2016		  
     (in thousands)  

Restructuring reserve beginning balance

    $ —    

Restructuring expenses incurred during the period

      1,223  

Amounts paid during the period

      (847 ) 
  

 

 

  

Restructuring reserve ending balance

    $ 376