Note Q - Quarterly Results of Operations (unaudited) - Schedule of Quarterly Operating Results (Details) - USD ($) $ / shares in Units, $ in Thousands |
3 Months Ended | 12 Months Ended | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Dec. 31, 2016 |
Sep. 30, 2016 |
Jun. 30, 2016 |
Mar. 31, 2016 |
Dec. 31, 2015 |
Sep. 30, 2015 |
Jun. 30, 2015 |
Mar. 31, 2015 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
|
| Revenue | |||||||||||
| Operating expenses: | |||||||||||
| Research and development | 7,963 | 4,287 | 4,988 | 3,234 | 4,716 | 4,328 | 2,768 | 2,119 | 20,472 | 13,931 | 11,917 |
| General and administrative | 2,873 | 3,104 | 4,287 | 3,736 | 2,566 | 2,152 | 3,188 | 977 | 14,000 | 8,883 | 4,526 |
| Restructuring Charges | 3,010 | ||||||||||
| Total operating expenses | 10,836 | 10,401 | 9,275 | 6,970 | 7,282 | 6,480 | 5,956 | 3,096 | 37,482 | 22,814 | 16,443 |
| Loss from operations | (10,836) | (10,401) | (9,275) | (6,970) | (7,282) | (6,480) | (5,956) | (3,096) | (37,482) | (22,814) | (16,443) |
| Other income (expense): | |||||||||||
| Loss on extinguishment of debt | (4,740) | (4,740) | 1,900 | ||||||||
| Interest expense related to amortization of debt issuance costs and discount | (391) | (390) | (393) | (442) | (475) | (479) | (477) | (477) | (1,616) | (1,909) | (1,114) |
| Interest expense on principal | (1,445) | (1,441) | (1,475) | (1,150) | (698) | (687) | (654) | (632) | (5,511) | (2,671) | (1,605) |
| Fair value adjustment | 2,723 | (1,299) | 20,763 | 10,278 | (764) | (2,089) | (22,661) | (1,762) | 32,465 | (27,276) | (7,223) |
| Interest and other income | 9 | 98 | 144 | 102 | 15 | 11 | 5 | 353 | 32 | 8 | |
| Total other income (expense) | 896 | (3,032) | 19,039 | 4,048 | (1,922) | (3,244) | (23,787) | (2,871) | 20,951 | (31,824) | (8,034) |
| Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest | (9,940) | (13,433) | 9,764 | (2,922) | (9,204) | (9,724) | (29,743) | (5,967) | (16,531) | (54,638) | (24,477) |
| Income tax benefit (expense) | 4 | 19 | 4 | (12) | 1 | (20) | (7) | 15 | (26) | 22 | |
| Net loss - basic and diluted | $ (9,936) | $ (13,414) | $ 9,768 | $ (2,934) | $ (9,203) | $ (9,744) | $ (29,743) | $ (5,974) | $ (16,516) | $ (54,664) | $ (24,455) |
| Net loss per share: | |||||||||||
| Basic (in dollars per share) | $ (0.68) | $ (0.92) | $ 0.59 | $ (0.20) | $ (0.64) | $ (0.68) | $ (2.45) | $ (2.50) | |||
| Diluted (in dollars per share) | $ (0.68) | $ (0.92) | $ (0.58) | $ (0.20) | $ (0.64) | $ (0.68) | $ (2.45) | $ (2.50) | |||