Note Q - Quarterly Results of Operations (unaudited)
 12 Months Ended
Dec. 31, 2016
Notes to Financial Statements  
Quarterly Financial Information [Text Block]
Q.
Quarterly Results of Operations (unaudited)
 
The following tables set forth unaudited quarterly statements of operations data for each of the quarters indicated. The financial statements for each of these quarters have been prepared on the same basis as the audited financial statements included herein and, in the opinion of management, include all adjustments, consisting only of normal recurring adjustments, necessary for the fair statement of the results of operations for these perio
ds. You should read this information together with our financial statements and related notes included herein. These quarterly
operating results are not necessarily indicative of the results for any future period.
 
   
Three-Months Ended
  
   
Dec 31,
    
Sep 30,
    
Jun 30,
    
Mar 31,
    
Dec 31,
    
Sep 30,
    
Jun 30,
    
Mar 31,
  
   
2016
    
2016
    
2016
    
2016
    
2015
    
2015
    
2015
    
2015
  
Revenue
   $
—
     $
—
     $
—
     $
—
     $
—
     $
—
     $
—
     $
—
  
Operating expenses:
                                                                
Research and development
    
7,963
      
4,287
      
4,988
      
3,234
      
4,716
      
4,328
      
2,768
      
2,119
  
General and administrative
    
2,873
      
3,104
      
4,287
      
3,736
      
2,566
      
2,152
      
3,188
      
977
  
Restructuring charges
    
—
      
3,010
      
—
      
—
      
—
      
—
      
—
      
—
  
Total operating expenses
    
10,836
      
10,401
      
9,275
      
6,970
      
7,282
      
6,480
      
5,956
      
3,096
  
Loss from operations
    
(10,836
)
    
(10,401
)
    
(9,275
)
    
(6,970
)
    
(7,282
)
    
(6,480
)
    
(5,956
)
    
(3,096
)
Other (expense) income:
                                                                
Loss on extinguishment of debt
    
—
      
—
      
—
      
(4,740
)
    
—
      
—
      
—
      
—
  
Interest expense related to amortization of debt issuance costs and discount
    
(391
)
    
(390
)
    
(393
)
    
(442
)
    
(475
)
    
(479
)
    
(477
)
    
(477
)
Interest expense on principal
    
(1,445
)
    
(1,441
)
    
(1,475
)
    
(1,150
)
    
(698
)
    
(687
)
    
(654
)
    
(632
)
Fair value adjustment
    
2,723
      
(1,299
)
    
20,763
      
10,278
      
(764
)
    
(2,089
)
    
(22,661
)
    
(1,762
)
Interest and other income
    
9
      
98
      
144
      
102
      
15
      
11
      
5
      
—
  
Total other income (expense)
    
896
      
(3,032
)
    
19,039
      
4,048
      
(1,922
)
    
(3,244
)
    
(23,787
)
    
(2,871
)
(Loss) income before income taxes
    
(9,940
)
    
(13,433
)
    
9,764
      
(2,922
)
    
(9,204
)
    
(9,724
)
    
(29,743
)
    
(5,967
)
Income tax benefit (expense)
    
4
      
19
      
4
      
(12
)
    
1
      
(20
)
    
—
      
(7
)
Net (loss) income
   $
(9,936
)
   $
(13,414
)
   $
9,768
     $
(2,934
)
   $
(9,203
)
   $
(9,744
)
   $
(29,743
)
   $
(5,974
)
                                                                 
Net (loss) income per share:
                                                                
Basic
   $
(0.68
)
   $
(0.92
)
   $
0.59
     $
(0.20
)
   $
(0.64
)
   $
(0.68
)
   $
(2.45
)
   $
(2.50
)
Diluted
   $
(0.68
)
   $
(0.92
)
   $
(0.58
)
   $
(0.20
)
   $
(0.64
)
   $
(0.68
)
   $
(2.45
)
   $
(2.50
)