Note 6 - Property and Equipment, Net
 12 Months Ended
Dec. 31, 2014
Property, Plant and Equipment [Abstract]  
Property, Plant and Equipment Disclosure [Text Block]

6. Property and Equipment, net


Property and equipment consist of the following:


   

December 31,

 
   

2014

   

2013

 
                 

Laboratory and production equipment

  $ 48,522     $ 34,443  

Office, software and computer equipment

    15,855       8,649  

Furniture and fixtures

    1,762       834  

Leasehold improvements

    5,212       3,952  
      71,351       47,878  

Less accumulated depreciation

    (35,853 )     (25,418 )
    $ 35,498     $ 22,460  

Depreciation and amortization expense for the years ended December 31, 2014, 2013 and 2012 was $10,897, $7,508 and $4,908, respectively.


As of December 31, 2014 and 2013, computer software costs included in property and equipment were $4,582 and $2,815, respectively. Amortization expense of capitalized computer software costs was $614, $283 and $280 for the years ended December 31, 2014, 2013 and 2012, respectively.