Commitments and Contingencies (Tables)
12 Months Ended
Dec. 31, 2013
Commitments and Contingencies Disclosure [Abstract]  
Schedule of rent expense
The following table presents rent expense included in the Consolidated Statement of Operations (in thousands):
 
Years Ended December 31,
 
2013
 
2012
 
2011
Rent expense
$
1,377

 
$
1,297

 
$
1,961

Schedule of future commitments and obligations under operating lease
Future commitments and obligations under this operating lease to be satisfied as they become due over the term are as follows (in thousands):
As of December 31:
 
The years ending December 31,
 
2014
$
1,286

2015
1,758

2016
2,253

2017
2,399

2018
2,459

Thereafter
17,557

Total
$
27,712

Schedule of Other Derivatives Not Designated as Hedging Instruments, Statements of Financial Performance and Financial Position, Location
The following table sets forth a summary of the changes in the fair value of the Company's derivative liability related to the Symyx asset purchase transaction (in thousands):
Minimum return to Symyx
$
67,000

Proceeds to Symyx from offering
(39,682
)
Initial fair value of derivative liability
(2,842
)
Reimbursement of offering related expenses
1,389

Mark-to-market adjustment
$
25,865

Schedule of payments made in connection with the note payable to Symyx
The following table presents payments made during the years ended December 31, 2013 and 2012 in connection with the note payable to Symyx (in thousands):
 
Years Ended December 31, 2013
 
Principal
 
Interest
 
Total
Symyx payments
$
26,516

 
$
437

 
$
26,953

 
Year Ended December 31, 2012
 
Principal
 
Interest
 
Total
Symyx payments
$
804

 
$
1,196

 
$
2,000

Schedule of Debt
The following table presents payments made during the year ended December 31, 2013 for interest owed under the terms of the Loan Agreement (in thousands):
 
Years Ended December 31, 2013
 
Principal
 
Interest
 
Total
SVB payments
$

 
$
350

 
$
350

Schedule of Maturities of Long-term Debt
Estimated principal payments related to the SVB term loan are as follows (in thousands):
As of December 31:
 
2014
$
2,000

2015
2,000

2016
21,000

Total
$
25,000