Statement of Cash Flows (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Cash flows from operating activities:      
Net loss $ (24,958) $ (22,264) $ (21,344)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation 800 1,086 1,109
Amortization of licenses, patents and other agreements 522 347 257
Amortization of debt issuance costs and debt discount 50 0 0
Loss (gain) on disposal of assets 0 6 (3)
Stock-based compensation 1,615 1,097 902
Gain on revaluation of warrants (20) 0 0
Changes in operating assets and liabilities:      
Accounts receivable (660) (1,735) 178
Inventories (1,503) 344 (423)
Prepaid expenses and other current assets (302) (322) (31)
Accounts payable 614 (87) (338)
Accrued liabilities 1,558 288 282
Accrued interest 115 0 13
Deferred revenue 869 236 166
Net cash used in operating activities (21,300) (21,004) (19,232)
Cash flows from investing activities:      
Purchases of property and equipment (1,817) (132) (558)
Payments to acquire licenses (404) (2,395) (373)
Net cash used in investing activities (2,221) (2,527) (931)
Cash flows from financing activities:      
Repayments of debt (1,055) (434) (268)
Proceeds from debt 12,000 0 0
Payments of debt issuance costs (222) 0 0
Proceeds from exercise of stock options 155 151 26
Proceeds from issuance of preferred stock 0 20,985 29,925
Proceeds from issuance of common stock, net of offering costs 40,772 0 0
Net cash provided by financing activities 51,650 20,702 29,683
Net increase (decrease) in cash and cash equivalents 28,129 (2,829) 9,520
Cash and cash equivalents — Beginning of period 33,900 36,729 27,209
Cash and cash equivalents — End of period 62,029 33,900 36,729
Supplemental disclosure of cash flow information —      
Cash paid for interest 545 36 31
Supplemental information on noncash activities:      
Issuance of stock options for intangible assets 70 0 215
Warrants issued with long-term debt 261 0 0
Property and equipment not yet paid 162 0 0
Licenses not yet paid 25 0 0
Accrued interest converted to principal 0 66 0
Fixed asset trade in credit 0 0 14
Accrued royalty applied to payment for license $ 0 $ 0 $ 50