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&lt;p style="MARGIN-TOP: 18px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;1. Nature of Operations
and Liquidity&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;
&lt;!-- xbrl,body --&gt;
&lt;p style="PADDING-BOTTOM: 0px; MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Nature of
Operations.&lt;/b&gt; Emisphere Technologies, Inc.
(&amp;#x201C;Emisphere,&amp;#x201D; &amp;#x201C;the Company,&amp;#x201D;
&amp;#x201C;our,&amp;#x201D; &amp;#x201C;us,&amp;#x201D; or &amp;#x201C;we&amp;#x201D;) is a
biopharmaceutical company that focuses on a unique and improved
delivery of therapeutic molecules or nutritional supplements using
its Eligen&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
Technology. These molecules are currently available or are under
development.&lt;/font&gt;&lt;/p&gt;
&lt;p style="PADDING-BOTTOM: 0px; MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Our core
business strategy is to pursue the commercialization of Oral
Eligen&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
B12, build new high-value partnerships and continue to expand upon
existing partnerships, evaluate new prescription Medical Foods
commercial opportunities, reprioritize the product pipeline, and
promote new uses for the Eligen&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
Technology.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 18px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;&lt;b&gt;Liquidity and Capital
Resources&lt;/b&gt;&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 6px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Since our inception in
1986, we have generated significant losses from operations and we
anticipate that we will continue to generate significant losses
from operations for the foreseeable future.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;As of June&amp;#xA0;30, 2013,
our working capital was $2.1&amp;#xA0;million, our accumulated deficit
was approximately $484.2&amp;#xA0;million and our stockholders deficit
was $82.4&amp;#xA0;million. Our operating loss was $1.8&amp;#xA0;million
and $1.4&amp;#xA0;million for the three months ended June&amp;#xA0;30, 2013
and 2012, respectively, and was $3.5 million and $3.2 million for
the six months ended June&amp;#xA0;30, 2013 and 2012, respectively. On
June&amp;#xA0;30, 2013 we had approximately $7.7 million of cash and
cash equivalents.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;We have limited capital
resources and operations to date have been funded with the proceeds
from collaborative research agreements, public and private equity
and debt financings and income earned on investments. As of
September&amp;#xA0;27, 2012, the Company was in default under the terms
of the MHR Convertible Notes and the Reimbursement Notes (as each
is defined and described in Note 9 to these Financial Statements)
issued to MHR Institutional Partners IIA LP, MHR Institutional
Partners II LP, MHR Capital Partners Master Account LP, and MHR
Capital Partners (100)&amp;#xA0;LP (together with their respective
affiliates, &amp;#x201C;MHR&amp;#x201D;). On April&amp;#xA0;26, 2013, the Company
entered into a restructuring agreement (the &amp;#x201C;Restructuring
Agreement&amp;#x201D;) with MHR regarding the restructuring of the terms
of the Company&amp;#x2019;s obligations to MHR under the MHR Convertible
Notes, the Reimbursement Notes, and certain Bridge Notes described
in Note 9 to these Financial Statements. A special committee of the
Company&amp;#x2019;s board of directors (the &amp;#x201C;Board&amp;#x201D;),
composed of independent directors, negotiated the terms of the
Restructuring Agreement and the transactions contemplated thereby
with the advice of its legal and financial advisors, and the
Restructuring Agreement was unanimously approved by the
disinterested members of the Board with the unanimous affirmative
recommendation of the special committee. On May&amp;#xA0;7, 2013,
pursuant to the transactions contemplated by the Restructuring
Agreement, each of the MHR Convertible Notes, Reimbursement Notes,
and Bridge Notes were amended and restated. Please see Note 9 to
these Financial Statements for more information regarding the
Company&amp;#x2019;s obligations to MHR, the Restructuring Agreement,
the terms of the amended and restated promissory notes issued to
MHR in connection therewith, and the other transactions
contemplated thereby.&lt;/font&gt;&lt;/p&gt;
&lt;p style="PADDING-BOTTOM: 0px; MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;
&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;Also on
April&amp;#xA0;26, 2013, the Company entered into an Amendment
No.&amp;#xA0;2 (the &amp;#x201C;Amendment&amp;#x201D;) to the Development and
License Agreement, dated June&amp;#xA0;21, 2008, between Novo Nordisk
A/S (&amp;#x201C;Novo Nordisk&amp;#x201D;) and the Company (as amended to
date, the &amp;#x201C;Development Agreement&amp;#x201D;). The Amendment
provides, among other things, for a payment of $10 million from
Novo Nordisk to the Company as a prepayment of certain development
milestone payments that would have otherwise become payable to the
Company under the Development Agreement upon the initiation of
Phase II and Phase III testing of an oral GLP-1 product by Novo
Nordisk, in exchange for a reduction in the rate of potential
future royalty payments arising from future sales of such products
developed under the Development Agreement. The Company received the
$10 million payment from Novo Nordisk contemplated by the Amendment
on May&amp;#xA0;6, 2013. The Company recorded the $10 million payment
as deferred revenue. Based upon the Company&amp;#x2019;s receipt of this
$10 million payment from Novo Nordisk, the Company estimates that
it will have sufficient cash to prepare for the market development
and domestic launch of, and to explore global markets opportunities
for Eligen&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
Oral B12, and otherwise continue operations through approximately
the second quarter of 2014. However, we do not have sufficient
resources to support a full commercial launch of Eligen&lt;font style="FONT-FAMILY: Times New Roman" size="1"&gt;&lt;sup style="POSITION: relative; BOTTOM: 0.8ex; VERTICAL-ALIGN: baseline"&gt;&amp;#xAE;&lt;/sup&gt;&lt;/font&gt;
Oral B12 in the U.S. market or to develop fully any new products or
technologies unless we are able to raise additional financing on
acceptable terms or secure funds from new or existing partners. We
cannot assure that such financing will be available on favorable
terms or at all. Additionally, if additional capital is raised
through the sale of equity or convertible debt securities, the
issuance of such securities would result in dilution to our
existing stockholders.&lt;/font&gt;&lt;/p&gt;
&lt;p style="MARGIN-TOP: 12px; MARGIN-BOTTOM: 0px"&gt;&lt;font style="FONT-FAMILY: Times New Roman" size="2"&gt;The Company is pursuing
several courses of action to address its deficiency in capital
resources, including the global commercialization of B12, seeking
new partnerships, leveraging existing partnerships, and capital
markets financings. While our plan is to raise capital and/or to
pursue partnering opportunities, we cannot be sure that our plans
will be successful. The Company estimates that if we fail to raise
additional capital or obtain substantial cash inflows from existing
or new partners prior to the third quarter of 2014, the Company
could be forced to cease operations. These conditions raise
substantial doubt about our ability to continue as a going concern.
Consequently, the audit reports prepared by our independent
registered public accounting firm relating to our financial
statements for&amp;#xA0;the years ended December&amp;#xA0;31, 2012, 2011
and 2010 include an explanatory paragraph expressing the
substantial doubt about our ability to continue as a going
concern.&lt;/font&gt;&lt;/p&gt;
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