Stock-based compensation (Tables)
3 Months Ended
Mar. 31, 2016
Schedule of stock-based compensation expense

Total compensation cost recognized for all stock‑based compensation awards in the condensed consolidated statements of operations and comprehensive loss was as follows (in thousands):

 

 

 

 

 

 

 

 

 

 

 

Three Months Ended

 

 

 

March 31, 

 

 

    

2016

    

2015

 

Research and development

 

$

3,458

 

$

64

 

General and administrative

 

 

752

 

 

1

 

Total stock-compensation expense

 

$

4,210

 

$

65

 

 

Schedule of changes in unvested restricted stock

 

 

 

 

 

 

 

 

 

    

 

    

Weighted

 

 

 

 

 

Average

 

 

 

 

 

Grant Date

 

 

 

 

 

Fair Value

 

 

 

Shares

 

Per Share

 

Unvested Restricted Common Stock as of December 31, 2015

 

1,596,853

 

$

0.0188

 

Issued

 

 

 

 —

 

Vested

 

(193,551)

 

$

0.0162

 

Unvested Restricted Common Stock as of March 31, 2016

 

1,403,302

 

$

0.0192

 

 

Schedule of stock option activity

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    

 

    

Weighted Average

    

Remaining

    

Aggregate Intrinsic

 

 

 

Shares

 

Exercise Price

 

Contractual Life

 

Value (in thousands)

 

Outstanding at December 31, 2015

 

1,713,385

 

$

6.31

 

9.6

 

$

15,580

 

Granted

 

695,312

 

$

18.68

 

 

 

 

 

 

Exercised

 

(8,673)

 

$

3.85

 

 

 

 

 

 

Cancelled

 

 —

 

 

 —

 

 

 

 

 

 

Outstanding at March 31, 2016

 

2,400,024

 

$

9.90

 

9.4

 

$

59,134

 

Vested and expected to vest at March 31, 2016

 

2,360,999

 

$

9.90

 

9.4

 

$

58,172

 

Exercisable at March 31, 2016

 

113,801

 

$

4.88

 

9.1

 

$

3,376

 

 

Employees and directors  
Schedule of assumptions used to value stock options

 

 

 

 

 

 

 

 

 

Three Months Ended

 

 

 

March 31, 

 

 

    

2016

    

2015

 

Risk free interest rate

 

1.5

%  

1.6

%

Expected dividend yield

 

 

 

Expected term (in years)

 

6.25

 

6.25

 

Expected volatility

 

80.0

%  

83.7

%

 

Non-employees  
Schedule of assumptions used to value stock options

 

 

 

 

 

 

 

 

 

Three Months Ended

 

 

 

March 31, 

 

 

    

2016

    

2015

 

Risk free interest rate

 

 —

 

1.9

%

Expected dividend yield

 

 

 

Expected term (in years)

 

 —

 

10.0

 

Expected volatility

 

 —

 

80.0

%