<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001837080</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0000031462</issuerCik>
			<issuerName>ECOLAB INC.</issuerName>


			    <secFileNumber>001-09328</secFileNumber>


			<issuerAddress>
				<com:street1>1 Ecolab Place</com:street1>
                				<com:city>St. Paul</com:city>
				<com:stateOrCountry>MN</com:stateOrCountry>
				<com:zipCode>55102</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>651-250-3323</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Gail  Peterson</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>E*Trade Financial Corporation</name>
				<address>
				<com:street1>3 Edison Drive</com:street1>
                				<com:city>Alpharetta</com:city>
				<com:stateOrCountry>GA</com:stateOrCountry>
				<com:zipCode>30005</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>934</noOfUnitsSold>
			<aggregateMarketValue>162283</aggregateMarketValue>
			<noOfUnitsOutstanding>284720960</noOfUnitsOutstanding>
			<approxSaleDate>05/16/2023</approxSaleDate>
			<securitiesExchangeName>NYSE</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>11/03/2019</acquiredDate>
         <natureOfAcquisitionTransaction>Employee stock plan transactions (1)</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>2501</amountOfSecuritiesAcquired>
                  <paymentDate>11/03/2019</paymentDate>
                  <natureOfPayment>(1)</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>


    		<remarks>(1) The seller acquired a total of 2501 shares between the dates of November 3, 2019 and February 22, 2023, inclusive, in connection with (i) the vesting of employee restricted stock unit awards and performance-based restricted stock unit awards in which no additional consideration was paid and (ii) the exercise of an employee stock option by means of a net exercise. The shares of the Issuer's common stock issued in connection with these transactions were registered on a Registration Statement on Form S-8.</remarks>

        <noticeSignature>
            <noticeDate>05/16/2023</noticeDate>
                        <signature>  /s/ David F. Duvick, as Attorney-in-Fact for Gail Peterson</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
