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Variable interest entities (Details) (USD $)
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12 Months Ended | ||
|---|---|---|---|
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Dec. 31, 2013
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Dec. 31, 2012
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Dec. 31, 2011
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Selling, General and Administrative Expenses [Member] | Biosciences [Member]
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| Variable Interest Entity [Line Items] | |||
| Reclassified accumulated translation adjustments | $ 83,000 | ||
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Oxford-Emergent Tuberculosis Consortium [Member]
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| Variable Interest Entity [Line Items] | |||
| Assets of variable interest entities included in consolidated balance sheet | 305,000 | 2,000,000 | |
| Liabilities of variable interest entities included in consolidated balance sheet | 249,000 | 2,000,000 | |
| Net loss | (1,800,000) | (10,700,000) | (13,200,000) |
| Net losses of variable interest entities included in consolidated statement of operations | $ (910,000) | $ (5,400,000) | $ (6,700,000) |