Net Loss Per Share Attributable to Common Stockholders - Summary of Computation of Basic and Diluted Net Loss Per Share Attributable to Common Stockholders (Detail) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Earnings Per Share [Abstract]                      
Net loss $ (15,635) $ (16,944) $ (16,176) $ (14,084) $ (14,587) $ (11,193) $ (11,355) $ (10,804) $ (62,839) $ (47,939) $ (18,518)
Accretion of preferred stock issuance costs to redemption value                   (204) (121)
Accrued dividends on preferred stock                     (2,267)
Net loss attributable to common stockholders-basic and diluted                 $ (62,839) $ (48,143) $ (20,906)
Weighted-average number of common shares-basic and diluted                 20,320,628 16,070,054 29,463
Net loss per share attributable to common stockholders-basic and diluted $ (0.76) $ (0.82) $ (0.86) $ (0.79) $ (0.82) $ (0.63) $ (0.64) $ (1.02) $ (3.09) $ (3.00) $ (709.57)