Related Party Transactions (Details)
1 Months Ended 12 Months Ended
Apr. 26, 2016
$ / shares
shares
Aug. 31, 2021
ft²
Feb. 28, 2021
USD ($)
$ / shares
shares
Mar. 31, 2018
USD ($)
$ / shares
shares
Dec. 31, 2021
USD ($)
Oct. 31, 2020
Public Offerings            
Proceeds from sale of stock         $ 31,989,000  
Owners of More Than 5% of Our Common Stock or Board of Directors            
Area of property subleased | ft²   7,585        
Sublease income - related party         235,000  
Angel Pharmaceuticals            
Owners of More Than 5% of Our Common Stock or Board of Directors            
Internal personnel costs         200,000  
Third-party costs         1,600,000  
Third-party costs expensed in prior years         600,000  
Third-party costs expensed in current years         1,000,000.0  
ICON plc            
Owners of More Than 5% of Our Common Stock or Board of Directors            
Clinical trial expense         $ 246,000,000,000  
Follow On Public Offering            
Public Offerings            
Issuance of common stock (in shares) | shares     9,783,660 8,117,647    
Share offering price | $ / shares     $ 3.50 $ 8.50    
Proceeds from sale of stock     $ 32,000,000.0 $ 64,900,000    
Follow On Public Offering | Orbimed Advisors LLC            
Public Offerings            
Issuance of common stock (in shares) | shares       1,285,714    
Owners of More Than 5% of Our Common Stock or Board of Directors            
Aggregate Purchase Price       $ 4,499,999    
Follow On Public Offering | Richard A. Miller, M.D.            
Public Offerings            
Issuance of common stock (in shares) | shares       100,000    
Owners of More Than 5% of Our Common Stock or Board of Directors            
Aggregate Purchase Price       $ 350,000    
Over-Allotment Option            
Public Offerings            
Issuance of common stock (in shares) | shares 502,618   1,212,231 1,058,823    
Share offering price | $ / shares $ 15.00          
Angel Pharmaceuticals Co. Ltd            
Related Party Transactions            
Ownership interest (as percent)         49.70% 53.20%