Significant Agreements (Narrative) (Details)
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1 Months Ended |
12 Months Ended |
22 Months Ended |
25 Months Ended |
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Mar. 31, 2014
USD ($)
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Dec. 31, 2013
USD ($)
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Dec. 31, 2015
USD ($)
item
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Dec. 31, 2014
USD ($)
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Dec. 31, 2013
USD ($)
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Dec. 31, 1999
USD ($)
shares
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Dec. 31, 2015
USD ($)
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Dec. 31, 2015
USD ($)
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| Debt And Credit Agreements [Line Items] |
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| Number of Patents | item |
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2
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| Cost incurred under the agreement |
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$ 15,419,000
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$ 18,372,000
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$ 20,470,000
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| Stanford license agreement |
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| Debt And Credit Agreements [Line Items] |
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| Issuance of common stock in conjunction with a license agreement | shares |
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30,000
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| Stanford license agreement | Annual Payment |
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| Debt And Credit Agreements [Line Items] |
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| Royalty payments to be made |
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$ 50,000
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| Centric Health Resources, Inc. |
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| Debt And Credit Agreements [Line Items] |
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| Initial agreement period |
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3 years
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| Agreement termination, written notice period |
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180 days
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| Agreement with PCAS |
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| Debt And Credit Agreements [Line Items] |
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| Initial agreement period |
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5 years
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| Automatic extension period |
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1 year
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| Agreement termination, written notice period |
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12 months
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| Right to terminate agreement if unable to manufacture product, period |
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9 months
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| Agreement with AAI Pharma [Member] |
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| Debt And Credit Agreements [Line Items] |
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| Initial agreement period |
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3 years
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| Automatic extension period |
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2 years
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| Agreement termination, written notice period |
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12 months
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| Termination notice period for manufacturer |
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18 months
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| Right to terminate agreement if unable to manufacture product, period |
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4 months
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| Purchase obligations |
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$ 0
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$ 0
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$ 0
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| Quotient Clinical Limited [Member] |
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| Debt And Credit Agreements [Line Items] |
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| Initial agreement period |
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1 year
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| Commitment amount related to service agreement |
$ 3,000,000
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| Cost incurred under the agreement |
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$ 2,900,000
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| Chiltern [Member] |
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| Debt And Credit Agreements [Line Items] |
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| Commitment amount related to service agreement |
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$ 3,100,000
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| Cost incurred under the agreement |
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$ 2,400,000
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