Summary of Stock Options Activity (Detail)
$ / shares in Units, $ in Thousands
9 Months Ended
Sep. 30, 2016
USD ($)
$ / shares
shares
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]  
Beginning Balance, Number of Options Outstanding | shares 5,360,257
Number of Options, Granted | shares 1,829,537
Number of Options, Exercised | shares (139,396)
Number of Options, Forfeited | shares (1,309,127)
Ending Balance, Number of Options Outstanding | shares 5,741,271
Number of Options, Vested and expected to vest at September 30, 2016 | shares 5,351,476
Number of Options, Exercisable at September 30, 2016 | shares 2,954,077
Beginning Balance, Weighted Average Exercise Price | $ / shares $ 51.53
Granted, Weighted Average Exercise Price | $ / shares 21.85
Exercised, Weighted Average Exercise Price | $ / shares 7.85
Forfeited, Weighted Average Exercise Price | $ / shares 54.27
Ending Balance, Weighted Average Exercise Price | $ / shares 42.51
Vested and expected to vest, Weighted Average Exercise Price | $ / shares 42.80
Exercisable, Weighted Average Exercise Price | $ / shares $ 43.14
Outstanding, Weighted Average Remaining Contractual Term (Years) 7 years 4 months 24 days
Vested and expected to vest, Weighted Average Remaining Contractual Term (Years) 7 years 2 months 12 days
Exercisable, Weighted Average Remaining Contractual Term (Years) 5 years 9 months 18 days
Outstanding, Aggregate Intrinsic Value | $ $ 52,392
Vested and expected to vest, Aggregate Intrinsic Value | $ 48,604
Exercisable, Aggregate Intrinsic Value | $ $ 27,713