Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Operating expenses:        
Research and development $ 54,338 $ 76,138 $ 196,675 $ 193,256
General and administrative 9,162 8,331 28,541 22,286
Acquired in-process research and development 500 12,000 800 12,000
Impairment of intangible asset     104,517  
Change in fair value of contingent purchase consideration   783 (24,936) 2,271
Total expenses 64,000 97,252 305,597 229,813
Operating loss (64,000) (97,252) (305,597) (229,813)
Other income (expense):        
Interest expense (2,108) (2,099) (6,318) (6,271)
Foreign currency gains (losses) (66) (101) (434) 2,004
Other income 252 179 473 252
Other expense, net (1,922) (2,021) (6,279) (4,015)
Loss before income taxes (65,922) (99,273) (311,876) (233,828)
Income tax benefit 227 628 33,467 508
Net loss $ (65,695) $ (98,645) $ (278,409) $ (233,320)
Basic and diluted net loss per common share $ (1.70) $ (2.62) $ (7.24) $ (6.62)
Basic and diluted weighted-average common shares outstanding 38,538 37,613 38,429 35,252