Share-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2012
Share-Based Compensation [Abstract]  
Share-based compensation expense recognized in the accompanying Consolidated Statements of Operations and Comprehensive Loss
                                         
    Three Months Ended September 30,     Nine Months Ended September 30,    

Cumulative
from

April 20, 2009
(Inception) to

September 30,

 
    2012     2011     2012     2011     2012  

Research and development

  $ 687     $ 192     $ 1,719     $ 398     $ 2,380  

General and administrative

    807       213       1,889       404       2,625  
   

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 

Total share-based compensation expense

  $ 1,494     $ 405     $ 3,608     $ 802     $ 5,005  
   

 

 

   

 

 

   

 

 

   

 

 

   

 

 

 
Summary of stock options activity
                                 
    Option Shares
Outstanding
    Weighted-
Average
Exercise
Price
    Weighted-
Average
Remaining
Contractual
Term (Years)
    Aggregate
Intrinsic
Value
 

Balance at December 31, 2011

    934,816     $ 4.88                  

Granted

    813,198       23.57                  

Exercised

    (13,510 )      3.12                  

Forfeited

    (21,306 )      9.07                  
   

 

 

                         

Balance at September 30, 2012

    1,713,198     $ 13.71       8.79     $ 14,294,555  
   

 

 

                         

Vested and expected to vest at September 30, 2012

    1,566,755     $ 13.11       8.74     $ 13,843,903  
   

 

 

                         

Vested at September 30, 2012

    499,338     $ 3.99       7.91     $ 8,218,956  
   

 

 

                         
Schedule of share-based compensation arrangements by share-based payment award
                 
    Three Months Ended September 30,  
    2012     2011  

Weighted-average grant-date fair value per share

  $ 14.32     $ 7.11  

Intrinsic value of options exercised

  $ —       $ 404,648  

Cash received from stock option exercises

  $ —       $ 162,518  

 

                 
    Nine Months Ended September 30,  
    2012     2011  

Weighted-average grant-date fair value per share

  $ 15.01     $ 8.71  

Intrinsic value of options exercised

  $ 223,319     $ 409,742  

Cash received from stock option exercises

  $ 42,149     $ 1,050,873  
Unrecognized share-based compensation expense
     

Unrecognized share-based

compensation expense

(in millions)

 

Weighted- average

remaining vesting period

(in years)

$ 13.3

  3.0