Property and Equipment, Net - Property and Equipment, Net (Detail) - USD ($)
$ in Thousands
Dec. 31, 2016
Dec. 31, 2015
Property, Plant and Equipment [Line Items]    
Property and equipment, gross $ 9,699 $ 8,280
Less accumulated depreciation and amortization 8,085 7,017
Property and equipment, net 1,614 1,263
Computer and Office Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment, gross 149 314
Laboratory Equipment [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment, gross 795 232
Furniture and Fixtures [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment, gross 173 155
Software [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment, gross   126
Leasehold Improvements [Member]    
Property, Plant and Equipment [Line Items]    
Property and equipment, gross $ 8,582 $ 7,453