Drug Supplier Project Plan – Total commitments for the Company’s drug supplier project plan were $3.2 million as of December 31, 2021, comprised of $1.6 million for the manufacture of prexigebersen drug product, $1.2 million for manufacture of the Company’s Grb2 drug substance, $0.3 million for manufacturing development and $0.1 million for testing services. The Company expects to incur $2.6 million of these commitments over the next 12 months.