Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Cash flows from operating activities:      
Net loss $ (8,973) $ (9,238) $ (16,492)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation and amortization 1,117 1,159 1,663
Write-off of abandoned patents and licensed technology 374 230 350
Gain on sale of property and equipment 0 (1) (15)
Compensation expense related to stock options and awards 990 1,902 3,159
Purchase of technology license with common stock 0 775 0
Changes in operating assets and liabilities:      
Receivables and other assets (4,588) (178) 412
Accounts payable and accrued expenses 557 (1,415) 1,635
Deferred revenue 2,768 250 (150)
Deferred rent (633) (432) (368)
Net cash used in operating activities (8,388) (6,948) (9,806)
Cash flows from investing activities:      
Maturities of marketable securities 30,652 20,183 10,556
Purchases of marketable securities (38,134) (20,114) (22,643)
Purchases of property and equipment (255) (72) (85)
Proceeds from the sale of property and equipment 0 3 15
Patent and licensed technology expenditures 0 (53) (269)
Net cash used in investing activities (7,737) (53) (12,426)
Cash flows from financing activities:      
Net proceeds from issuance of common stock 7,758 3 3,925
Payment of withholding taxes for net settlement of restricted stock units (14) (23) (59)
Net cash provided by (used in) financing activities 7,744 (20) 3,866
Net decrease in cash and cash equivalents (8,381) (7,021) (18,366)
Cash and cash equivalents at beginning of year 13,450 20,471 38,837
Cash and cash equivalents at end of year $ 5,069 $ 13,450 $ 20,471