Stock Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2016
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]  
Summary of Total Stock-Based Compensation Expense

Total stock-based compensation expense was allocated to research and development, manufacturing and production and general and administrative expense as follows (in thousands):

 

 

 

Year Ended December 31,

 

 

 

2016

 

 

2015

 

 

2014

 

Research and development

 

$

290

 

 

$

392

 

 

$

785

 

Manufacturing and production

 

 

111

 

 

 

159

 

 

 

229

 

General and administrative

 

 

589

 

 

 

1,351

 

 

 

2,145

 

Total stock-based compensation expense

 

$

990

 

 

$

1,902

 

 

$

3,159

 

Cash received from RSU grants and options exercised

 

$

1

 

 

$

3

 

 

$

2

 

 
Summary of Stock Option Transactions under Company's Stock Incentive Plans

The following table summarizes stock option transactions under the Company’s stock incentive plans for the years ended December 31, 2016, 2015 and 2014:

 

 

 

Shares

 

 

Weighted Average

Exercise Price

 

Outstanding December 31, 2013

 

 

840,419

 

 

$

31.50

 

Granted

 

 

188,961

 

 

$

13.99

 

Exercised

 

 

—

 

 

$

—

 

Forfeited

 

 

(169,937

)

 

$

36.91

 

Outstanding December 31, 2014

 

 

859,443

 

 

$

26.58

 

Granted

 

 

235,675

 

 

$

10.06

 

Exercised

 

 

—

 

 

$

—

 

Forfeited

 

 

(149,534

)

 

$

21.51

 

Outstanding December 31, 2015

 

 

945,584

 

 

$

23.27

 

Granted

 

 

339,975

 

 

$

3.51

 

Exercised

 

 

—

 

 

$

—

 

Forfeited

 

 

(82,758

)

 

$

24.37

 

Outstanding December 31, 2016

 

 

1,202,801

 

 

$

17.61

 

Vested and unvested options expected to vest as of December 31, 2016

 

 

1,166,012

 

 

$

18.00

 

 
Summary of Outstanding RSUs

A summary of the outstanding RSUs as of December 31, 2016, and changes during the year then ended is presented below:

 

 

 

Shares

 

 

Weighted Average

Grant-Date Fair

Value per Share

 

Unvested at December 31, 2015

 

 

104,074

 

 

$

12.55

 

Granted

 

 

—

 

 

$

—

 

Vested

 

 

(59,568

)

 

$

13.43

 

Cancelled

 

 

—

 

 

$

—

 

Unvested at December 31, 2016

 

 

44,506

 

 

$

11.38