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  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001741849</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001681087</issuerCik>
      <issuerName>AvroBio, Inc.</issuerName>
      <secFileNumber>001-38537</secFileNumber>
      <issuerAddress>
        <com:street1>100 Technology Square</com:street1>
        <com:street2>Sixth Floor</com:street2>
        <com:city>Cambridge</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02139</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>6179148420</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Geoff MacKay</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Former CEO</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>AvroBio, Inc</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>UBS Financial Services Inc</name>
        <address>
          <com:street1>1000 Harbor Blvd</com:street1>
          <com:street2>3rd Floor</com:street2>
          <com:city>Weehawken</com:city>
          <com:stateOrCountry>NJ</com:stateOrCountry>
          <com:zipCode>07086</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>146927</noOfUnitsSold>
      <aggregateMarketValue>173373.86</aggregateMarketValue>
      <noOfUnitsOutstanding>44105078</noOfUnitsOutstanding>
      <approxSaleDate>06/07/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>12/23/2022</acquiredDate>
      <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>AvroBio, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>100928</amountOfSecuritiesAcquired>
      <paymentDate>12/23/2022</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>01/24/2023</acquiredDate>
      <natureOfAcquisitionTransaction>Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>AvroBio, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>45999</amountOfSecuritiesAcquired>
      <paymentDate>01/24/2023</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Kali M MacKay Irrevocable Trust</name>
        <address>
          <com:street1>1 Franklin St</com:street1>
          <com:street2>Apt 4304</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>AvroBio, Inc.</securitiesClassTitle>
      <saleDate>05/24/2023</saleDate>
      <amountOfSecuritiesSold>72604</amountOfSecuritiesSold>
      <grossProceeds>92930</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>The Mac C MacKay Irrevocable Trust</name>
        <address>
          <com:street1>1 Franklin St</com:street1>
          <com:street2>Apt 4304</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>AvroBio, Inc.</securitiesClassTitle>
      <saleDate>05/24/2023</saleDate>
      <amountOfSecuritiesSold>72604</amountOfSecuritiesSold>
      <grossProceeds>95108</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoff MacKay</name>
        <address>
          <com:street1>1 Franklin St</com:street1>
          <com:street2>Apt 4304</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>AvroBio, Inc.</securitiesClassTitle>
      <saleDate>05/24/2023</saleDate>
      <amountOfSecuritiesSold>292215</amountOfSecuritiesSold>
      <grossProceeds>372079</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoff MacKay</name>
        <address>
          <com:street1>1 Franklin St</com:street1>
          <com:street2>Apt 4304</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>AvroBio, Inc.</securitiesClassTitle>
      <saleDate>05/25/2023</saleDate>
      <amountOfSecuritiesSold>186841</amountOfSecuritiesSold>
      <grossProceeds>229407</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Geoff MacKay</name>
        <address>
          <com:street1>1 Franklin St</com:street1>
          <com:street2>Apt 4304</com:street2>
          <com:city>Boston</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02110</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>AvroBio, Inc.</securitiesClassTitle>
      <saleDate>06/05/2023</saleDate>
      <amountOfSecuritiesSold>7152</amountOfSecuritiesSold>
      <grossProceeds>7947</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/07/2023</noticeDate>
      <signature>/s/ UBS Financial Services Inc, as attorney-in-fact for Geoff MacKay</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
