| Cash Flow, Supplemental Disclosures [Text Block] |
Note 14 — Supplemental Cash Flow Disclosures — Non-Cash Transactions Non-cash Investing and Financing transactions for years ended December 31 include: | | | 2014 | | 2013 | | | Conversion of convertible debt to common stock | | $ | 3,067,423 | | $ | 523,927 | | | Reclassification of the unamortized balance of debt discount and derivative liability, related to the extinguishment and conversion of the subordinated convertible debt, to additional paid-in capital | | | 2,860,627 | | | — | | | Derivative liability created from conversion option embedded in Deerfield convertible credit facility | | | 8,825,935 | | | — | | | Effect of modification of convertible debt | | | — | | | 151,032 | | | Common Stock issued for committed equity financing facility | | | — | | | 204,015 | | | Warrants issued for term loan modification | | | — | | | 151,758 | | | Warrants issued for term loan | | | — | | | 568,324 | | | Common stock and warrants issued for release of security interest in patents | | | — | | | 325,693 | | | Warrants issued in connection with convertible debt and equity facility | | | 29,137,682 | | | 1,353,842 | | | Derivative liability for embedded conversion option | | | — | | | 965,484 | | | Common stock issued for professional services | | | — | | | 17,850 | | | Common stock issued for settlement of contingency | | | 39,150 | | | 39,150 | | | Reclassification of warrant derivative liability to additional paid-in capital as a result of the expiration of non-standard anti-dilution clause contained in warrants | | | 1,331,776 | | | — | | | Issuance of common stock in connection with convertible debt facility | | | 1,050,000 | | | — | | | Common stock issued to satisfy contingent consideration | | | 127 | | | — | | | Accrued property and equipment | | | 64,108 | | | — | | Cash paid for interest was $379,000 and $564,000 in 2014 and 2013, respectively. There were no income taxes paid in 2014 and 2013. |