Consolidated Statements of Operations and Comprehensive Loss (Parenthetical) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Research and Development [Member]      
Stock compensation expense $ 1,192 $ 1,277 $ 1,158
General and Administrative [Member]      
Stock compensation expense $ 1,676 $ 1,652 $ 1,447