Collaborative Arrangements and Revenue Recognition - Additional Information (Detail)
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12 Months Ended |
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Dec. 31, 2016
USD ($)
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Dec. 31, 2016
GBP (£)
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Dec. 31, 2015
USD ($)
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Dec. 31, 2014
USD ($)
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Expected grant revenue |
$ 1,109,000
|
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$ 1,650,000
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$ 1,337,000
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| RTI Surgical Inc [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Commercial milestone revenue |
0
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| RTI Surgical Inc [Member] | Maximum [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Cash payment eligible to receive on achievement of certain commercial milestone |
35,500,000
|
|
|
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| Healios License Agreement [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Up-front cash payment received |
15,000,000
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| Potential near-term payment received |
$ 10,000,000
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| Collaborative expansion period |
2 years
|
2 years
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| License revenue |
$ 15,000,000
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| Healios License Agreement [Member] | Regulatory and Sales Milestones [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Commercial milestone revenue |
225,000,000
|
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| Chugai Collaboration [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Up-front cash payment received |
10,000,000
|
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| UNITED KINGDOM | Innovate UK [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Expected grant revenue |
2,500,000
|
£ 2,000,000
|
|
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| UNITED KINGDOM | Innovate UK [Member] | Clinical Product And Related Costs [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Expected grant revenue |
900,000
|
750,000
|
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| UNITED KINGDOM | Innovate UK [Member] | Clinical Site Costs and Service Costs [Member] |
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| Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |
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| Expected grant revenue |
$ 157,000
|
£ 1,250,000
|
$ 130,000
|
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