Statements of Cash Flows - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
OPERATING ACTIVITIES:    
Net loss $ (105,584) $ (93,961)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 11,177 8,026
Amortization of operating lease right-of-use assets 415 380
Payment of security deposit and leasehold improvements for long-term lease   (2)
Change in operating lease liability (404) (358)
Changes in operating assets and liabilities:    
Financed insurance premium (4,435) (3,222)
Prepaid expenses (1,654) 2,207
Accounts payable 8,821 (8,044)
Accrued expenses and other current liabilities (3,346) 14,213
Amortization of insurance premium 4,282 2,552
Net cash used in operating activities (90,728) (78,209)
INVESTING ACTIVITIES:    
Purchase of available-for-sale securities (121,589) (134,659)
Proceeds from sale of available-for-sale securities 5,538 17,109
Proceeds from maturities of available-for-sale securities 128,484 98,081
Net cash provided by/(used in) investing activities 12,433 (19,469)
FINANCING ACTIVITIES:    
Proceeds from financed insurance premium 4,434 3,222
Repayments of short-term borrowings (4,718) (2,148)
Exercise of stock options for common stock under Equity Incentive Plan 511 1,817
Exercise of Warrants 69  
Net cash provided by financing activities 74,717 136,294
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS (3,578) 38,616
Cash and cash equivalents at beginning of period 57,466 18,850
Cash and cash equivalents at end of period 53,888 57,466
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:    
Operating lease right-of-use asset obtained in exchange for operating lease liability   57
Unrealized gain (loss) on marketable securities 5 (110)
Secondary Public Offering, 2020    
FINANCING ACTIVITIES:    
Proceeds from stock issuance, net of cash issuance costs   134,102
February Offering, 2021    
FINANCING ACTIVITIES:    
Proceeds from stock issuance, net of cash issuance costs $ 74,421  
Private Placement    
FINANCING ACTIVITIES:    
Payment of offering costs   (206)
Shelf Registration Statement    
FINANCING ACTIVITIES:    
Payment of offering costs   (493)
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION:    
Stock issuance costs in accrued expenses   $ 2