LICENSE AGREEMENT - Miami University (Details) - USD ($)
12 Months Ended
Dec. 14, 2020
Oct. 28, 2020
Dec. 31, 2021
Dec. 31, 2020
Agreements        
Research and development     $ 62,570,000 $ 61,788,000
Operating expenses     105,618,000 94,466,000
General and administrative     43,048,000 32,678,000
Accrued expenses and other current liabilities     16,559,000 20,189,000
Accounts payable     9,461,000 640,000
2020 license agreement | University of Miami        
Agreements        
Amount of first payment to be made for license issue fee   $ 1,100,000    
Amount of second payment to be made for license issue fee, due on first anniversary of the date of license   500,000    
Payment to be made on achievement of specified patenting and development milestones   2,200,000    
Payment to be made on achievement of late stage regulatory milestones   $ 4,100,000    
Agreement term   10 years    
Written notice period for termination of agreement   60 days    
Written notice period of material breach leading to termination   60 days    
Research and development     300,000 2,000,000.0
General and administrative     0 36,000
Accrued expenses and other current liabilities     300,000 1,600,000
2020 license agreement | University of Miami | Minimum        
Agreements        
Royalties payment (as a percent)   0.88%    
Non-royalty sublicensing revenue payment (as a percent)   15.00%    
2020 license agreement | University of Miami | Maximum        
Agreements        
Royalties payment (as a percent)   5.00%    
Non-royalty sublicensing revenue payment (as a percent)   25.00%    
2020 research agreement and amendment | University of Miami        
Agreements        
Consideration $ 300,000      
Research and development     200,000 3,740
Accrued expenses and other current liabilities     $ 200,000 $ 3,740