CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
REVENUES:        
Manufacturing and royalty revenues $ 110,250 $ 114,072 $ 353,444 $ 355,978
Product sales, net 69,802 37,903 176,695 106,212
Research and development revenue 189 678 2,042 3,047
Total revenues 180,241 152,653 532,181 465,237
EXPENSES:        
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 35,456 33,806 97,165 104,198
Research and development 99,444 92,558 297,523 250,718
Selling, general and administrative 91,145 89,497 276,985 224,086
Amortization of acquired intangible assets 15,323 14,207 45,636 43,479
Total expenses 241,368 230,068 717,309 622,481
OPERATING LOSS (61,127) (77,415) (185,128) (157,244)
OTHER (EXPENSE) INCOME, NET:        
Interest income 912 865 2,917 2,320
Interest expense (3,375) (3,325) (9,993) (9,928)
Change in the fair value of contingent consideration (1,000) 1,200 3,100 2,700
Gain on the Gainesville Transaction   26   9,937
Other (expense) income, net (752) 629 (970) 1,003
Total other (expense) income, net (4,215) (605) (4,946) 6,032
LOSS BEFORE INCOME TAXES (65,342) (78,020) (190,074) (151,212)
(BENEFIT) PROVISION FOR INCOME TAXES (2,655) 2,995 (2,771) 6,569
NET LOSS $ (62,687) $ (81,015) $ (187,303) $ (157,781)
LOSS PER COMMON SHARE:        
Basic and diluted (in dollars per share) $ (0.41) $ (0.54) $ (1.24) $ (1.06)
WEIGHTED AVERAGE NUMBER OF COMMON SHARES OUTSTANDING:        
Basic and Diluted (in shares) 151,652 149,512 151,261 148,828
COMPREHENSIVE LOSS        
Net loss $ (62,687) $ (81,015) $ (187,303) $ (157,781)
Holding (loss) gains, net of a tax (benefit) provision of $(129), $(5), $445 and $165, respectively (261) 14 988 424
COMPREHENSIVE LOSS $ (62,948) $ (81,001) $ (186,315) $ (157,357)