CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $)
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
REVENUES:    
Manufacturing and royalty revenues $ 128,744,000 $ 111,280,000
Product sales, net 31,137,000 17,079,000
Research and development revenue 1,333,000 1,853,000
Total revenues 161,214,000 130,212,000
EXPENSES:    
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 39,974,000 38,839,000
Research and development 70,278,000 52,140,000
Selling, general and administrative 63,050,000 42,550,000
Amortization of acquired intangible assets 15,220,000 12,576,000
Total expenses 188,522,000 146,105,000
OPERATING LOSS (27,308,000) (15,893,000)
OTHER EXPENSE, NET:    
Interest income 660,000 511,000
Interest expense (3,288,000) (3,356,000)
Other expense, net (211,000) (1,850,000)
Total other expense, net (2,839,000) (4,695,000)
LOSS BEFORE INCOME TAXES (30,147,000) (20,588,000)
PROVISION FOR INCOME TAXES 510,000 3,766,000
NET LOSS (30,657,000) (24,354,000)
LOSS PER COMMON SHARE    
Basic and diluted (in dollars per share) $ (0.21) $ (0.17)
WEIGHTED AVERAGE NUMBER OF COMMON SHARES OUTSTANDING:    
Basic and diluted (in shares) 148,089,000 143,358,000
COMPREHENSIVE LOSS    
Net loss (30,657,000) (24,354,000)
Unrealized gains (losses) on marketable securities, net of tax:    
Holding gains (losses), net of tax of $209 and $1,453, respectively 489,000 (2,531,000)
Unrealized gains (losses) on marketable securities 489,000 (2,531,000)
COMPREHENSIVE LOSS $ (30,168,000) $ (26,885,000)