Consolidated Statements of Cash Flows - USD ($)
$ in Thousands |
12 Months Ended |
40 Months Ended |
Dec. 31, 2021 |
Dec. 31, 2020 |
Dec. 31, 2019 |
Dec. 31, 2020 |
| Operating Activities: |
|
|
|
|
| Net loss |
$ (33,152)
|
$ (14,730)
|
$ (16,395)
|
|
| Adjustments to reconcile net loss to net cash used in operating activities: |
|
|
|
|
| Depreciation |
27
|
32
|
31
|
|
| Amortization [note 5] |
223
|
223
|
223
|
|
| Stock-based compensation [note 12[c]] |
2,187
|
1,286
|
1,201
|
|
| Shares issued as settlement with trade vendor |
41
|
|
|
|
| Cumulative adjustment on adoption of lease standard |
|
|
(3)
|
|
| Changes in operating assets and liabilities: |
|
|
|
|
| Grant receivable [note 4] |
(153)
|
|
|
|
| Prepaid expenses and other assets |
(228)
|
(452)
|
194
|
|
| Accounts payable |
509
|
(527)
|
715
|
|
| Accrued liabilities other |
(245)
|
280
|
(328)
|
|
| Accrued clinical liabilities |
899
|
66
|
(812)
|
|
| Accrued compensation |
466
|
358
|
(52)
|
|
| Lease obligation |
(14)
|
(10)
|
10
|
|
| Net cash used in operating activities |
(29,440)
|
(13,474)
|
(15,216)
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from exercise of warrants |
338
|
3,231
|
4,199
|
|
| Receipt of convertible debt from SVB [note 10] |
14,929
|
|
|
|
| Net cash provided by financing activities |
36,610
|
32,680
|
17,325
|
|
| Investing Activities: |
|
|
|
|
| Purchase of property and equipment |
|
(17)
|
(53)
|
|
| Purchase of investments |
|
|
(25)
|
|
| Maturities of investments |
|
|
5,114
|
|
| Net cash provided by (used in) investing activities |
|
(17)
|
5,036
|
|
| Effect of exchange rate changes on cash |
(1)
|
|
4
|
|
| Net increase (decrease) in cash, cash equivalents and restricted cash |
7,169
|
19,189
|
7,149
|
|
| Cash, cash equivalents and restricted cash at beginning of year |
35,903
|
16,714
|
9,565
|
|
| Cash, cash equivalents and restricted cash at end of year |
43,072
|
35,903
|
16,714
|
$ 35,903
|
| LPC [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Financing costs relating to purchase agreement with Lincoln Park Capital |
|
|
|
$ (500)
|
| LPC [Member] | Purchase Agreement [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |
|
|
792
|
|
| Financing costs relating to purchase agreement with Lincoln Park Capital |
|
(14)
|
|
|
| December 2019 Public Offering [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Financing costs relating to purchase agreement with Lincoln Park Capital |
|
(34)
|
|
|
| Proceeds from public offering, net of issuance costs |
|
|
$ 12,334
|
|
| April 2020 Private Placement [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |
|
1,579
|
|
|
| July 2020 Registered Direct Offering [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from purchase agreement with Lincoln Park Capital, net of issuance costs |
|
5,307
|
|
|
| May 2021 Public Offering [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from offering, net of issuance costs |
$ 21,343
|
|
|
|
| August 2020 Public Offering [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from offering, net of issuance costs |
|
6,822
|
|
|
| December 2020 Public Offering [Member] |
|
|
|
|
| Financing Activities: |
|
|
|
|
| Proceeds from offering, net of issuance costs |
|
$ 15,789
|
|
|